Přístupnostní navigace
E-application
Search Search Close
Publication detail
VOJTOVÁ, L. MICHLOVSKÁ, L. GRÉZLOVÁ, V. DORAZILOVÁ, J. ŠMERKOVÁ, K. KOPEL, P. ADAM, V. HLINÁKOVÁ, K. DIVIŠ, P. LUKÁŠOVÁ, V. RAMPICHOVÁ, M. SUCHÝ, T. BARTOŠ, M. SEDLÁČEK, R. BALLAY, R. MELICHERČÍK, P. KLAPKOVÁ, E. VIŠTEJNOVÁ, L. KLEIN, P.
Original Title
Efficacy of Various Antimicrobial Agents Loaded in Resorbable Porous Bone Cement Useful in the Treatment of Osteomyelitis
Type
abstract
Language
English
Original Abstract
All surgeries carry the risk of complications due to bacterial infections. Infected hip or knee revisions are generally accompanied with local and systemic antibiotic therapy. Generally, in two-stage revisions, non- degradable poly(methyl methacrylate) spacers loaded with antibiotics are used. Only 3-5% of the antibiotic appears to be released during in vivo testing. To overcome this issue, we have developed a biodegradable, “self- setting”, thixotropic and osteoconductive bone cement based on polymer and calcium phosphate. In the presented work, we loaded the cement with either vancomycin or biogenic selenium nanoparticles (SeNPs) to compare their release and antimicrobial efficiency in vitro.
Keywords
calcium phosphate, bone cement, biodegradable, self-setting, antibiotic, vancomycin, selenium nanoparticles, release, in vivo, in vitro
Authors
VOJTOVÁ, L.; MICHLOVSKÁ, L.; GRÉZLOVÁ, V.; DORAZILOVÁ, J.; ŠMERKOVÁ, K.; KOPEL, P.; ADAM, V.; HLINÁKOVÁ, K.; DIVIŠ, P.; LUKÁŠOVÁ, V.; RAMPICHOVÁ, M.; SUCHÝ, T.; BARTOŠ, M.; SEDLÁČEK, R.; BALLAY, R.; MELICHERČÍK, P.; KLAPKOVÁ, E.; VIŠTEJNOVÁ, L.; KLEIN, P.
Released
14. 6. 2021
Publisher
eCM Meeting Abstracts
ISBN
2522-235X
Periodical
eCM Periodical
Year of study
2021
Number
1
State
Swiss Confederation
Pages from
21
Pages to
Pages count
URL
https://www.ecmconferences.org/abstracts/2021/Collection1/c1.html
BibTex
@misc{BUT175280, author="Lucy {Vojtová} and Lenka {Michlovská} and Veronika {Grézlová} and Jana {Matulová} and Kristýna {Šmerková} and Pavel {Kopel} and Vojtěch {Adam} and Kristýna {Hlináková} and Pavel {Diviš} and Věra {Lukášová} and Michaela {Rampichová} and Tomáš {Suchý} and Martin {Bartoš} and Radek {Sedláček} and Rastislav {Ballay} and Pavel {Melicherčík} and Eva {Klapková} and Lucie {Vištejnová} and Pavel {Klein}", title="Efficacy of Various Antimicrobial Agents Loaded in Resorbable Porous Bone Cement Useful in the Treatment of Osteomyelitis", year="2021", journal="eCM Periodical", volume="2021", number="1", pages="21--21", publisher="eCM Meeting Abstracts", issn="2522-235X", url="https://www.ecmconferences.org/abstracts/2021/Collection1/c1.html", note="abstract" }