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VOJTOVÁ, L. MICHLOVSKÁ, L. GRÉZLOVÁ, V. DORAZILOVÁ, J. ŠMERKOVÁ, K. KOPEL, P. ADAM, V. HLINÁKOVÁ, K. DIVIŠ, P. LUKÁŠOVÁ, V. RAMPICHOVÁ, M. SUCHÝ, T. BARTOŠ, M. SEDLÁČEK, R. BALLAY, R. MELICHERČÍK, P. KLAPKOVÁ, E. VIŠTEJNOVÁ, L. KLEIN, P.
Originální název
Efficacy of Various Antimicrobial Agents Loaded in Resorbable Porous Bone Cement Useful in the Treatment of Osteomyelitis
Typ
abstrakt
Jazyk
angličtina
Originální abstrakt
All surgeries carry the risk of complications due to bacterial infections. Infected hip or knee revisions are generally accompanied with local and systemic antibiotic therapy. Generally, in two-stage revisions, non- degradable poly(methyl methacrylate) spacers loaded with antibiotics are used. Only 3-5% of the antibiotic appears to be released during in vivo testing. To overcome this issue, we have developed a biodegradable, “self- setting”, thixotropic and osteoconductive bone cement based on polymer and calcium phosphate. In the presented work, we loaded the cement with either vancomycin or biogenic selenium nanoparticles (SeNPs) to compare their release and antimicrobial efficiency in vitro.
Klíčová slova
calcium phosphate, bone cement, biodegradable, self-setting, antibiotic, vancomycin, selenium nanoparticles, release, in vivo, in vitro
Autoři
VOJTOVÁ, L.; MICHLOVSKÁ, L.; GRÉZLOVÁ, V.; DORAZILOVÁ, J.; ŠMERKOVÁ, K.; KOPEL, P.; ADAM, V.; HLINÁKOVÁ, K.; DIVIŠ, P.; LUKÁŠOVÁ, V.; RAMPICHOVÁ, M.; SUCHÝ, T.; BARTOŠ, M.; SEDLÁČEK, R.; BALLAY, R.; MELICHERČÍK, P.; KLAPKOVÁ, E.; VIŠTEJNOVÁ, L.; KLEIN, P.
Vydáno
14. 6. 2021
Nakladatel
eCM Meeting Abstracts
ISSN
2522-235X
Periodikum
eCM Periodical
Ročník
2021
Číslo
1
Stát
Švýcarská konfederace
Strany od
21
Strany do
Strany počet
URL
https://www.ecmconferences.org/abstracts/2021/Collection1/c1.html
BibTex
@misc{BUT175280, author="Lucy {Vojtová} and Lenka {Michlovská} and Veronika {Grézlová} and Jana {Matulová} and Kristýna {Šmerková} and Pavel {Kopel} and Vojtěch {Adam} and Kristýna {Hlináková} and Pavel {Diviš} and Věra {Lukášová} and Michaela {Rampichová} and Tomáš {Suchý} and Martin {Bartoš} and Radek {Sedláček} and Rastislav {Ballay} and Pavel {Melicherčík} and Eva {Klapková} and Lucie {Vištejnová} and Pavel {Klein}", title="Efficacy of Various Antimicrobial Agents Loaded in Resorbable Porous Bone Cement Useful in the Treatment of Osteomyelitis", year="2021", journal="eCM Periodical", volume="2021", number="1", pages="21--21", publisher="eCM Meeting Abstracts", issn="2522-235X", url="https://www.ecmconferences.org/abstracts/2021/Collection1/c1.html", note="abstract" }