Publication detail

In Vivo Organic Bioelectronics for Neuromodulation

BERGGREN, M. GLOWACKI, E. SIMON, D. STAVRINIDIOU, E. TYBRANDT, K.

Original Title

In Vivo Organic Bioelectronics for Neuromodulation

Type

journal article in Web of Science

Language

English

Original Abstract

The nervous system poses a grand challenge for integration with modern electronics and the subsequent advances in neurobiology, neuroprosthetics, and therapy which would become possible upon such integration. Due to its extreme complexity, multifaceted signaling pathways, and similar to 1 kHz operating frequency, modern complementary metal oxide semiconductor (CMOS) based electronics appear to be the only technology platform at hand for such integration. However, conventional CMOS-based electronics rely exclusively on electronic signaling and therefore require an additional technology platform to translate electronic signals into the language of neurobiology. Organic electronics are just such a technology platform, capable of converting electronic addressing into a variety of signals matching the endogenous signaling of the nervous system while simultaneously possessing favorable material similarities with nervous tissue. In this review, we introduce a variety of organic material platforms and signaling modalities specifically designed for this role as "translator" , focusing especially on recent implementation in in vivo neuromodulation. We hope that this review serves both as an informational resource and as an encouragement and challenge to the field.

Keywords

conductive polymer; neurite out growth; electrical-stimulation; polypyrrole; tissue; electrodes; delivery; release; reduction; oxygen

Authors

BERGGREN, M.; GLOWACKI, E.; SIMON, D.; STAVRINIDIOU, E.; TYBRANDT, K.

Released

23. 2. 2022

Publisher

American Chemical Society

Location

WASHINGTON

ISBN

0009-2665

Periodical

Chemical Reviews

Year of study

122

Number

4

State

United States of America

Pages from

4826

Pages to

4846

Pages count

21

URL

https://pubs.acs.org/doi/10.1021/acs.chemrev.1c00390

Full text in the Digital Library

http://hdl.handle.net/11012/208225

BibTex

@article{BUT176412,
  author="Magnus {Berggren} and Eric Daniel {Glowacki} and Daniel T. {Simon} and Eleni {Stavrinidiou} and Klas {Tybrandt}",
  title="In Vivo Organic Bioelectronics for Neuromodulation",
  journal="Chemical Reviews",
  year="2022",
  volume="122",
  number="4",
  pages="4826--4846",
  doi="10.1021/acs.chemrev.1c00390",
  issn="0009-2665",
  url="https://pubs.acs.org/doi/10.1021/acs.chemrev.1c00390"
}