Publication detail

NKG2D Natural Killer Cell Receptor-A Short Description and Potential Clinical Applications

SIEMASZKO, J. MARZEC-PRZYSZLAK, A. BOGUNIA-KUBIK, K.

Original Title

NKG2D Natural Killer Cell Receptor-A Short Description and Potential Clinical Applications

Type

journal article in Web of Science

Language

English

Original Abstract

Natural Killer (NK) cells are natural cytotoxic, effector cells of the innate immune system. They can recognize transformed or infected cells. NK cells are armed with a set of activating and inhibitory receptors which are able to bind to their ligands on target cells. The right balance between expression and activation of those receptors is fundamental for the proper functionality of NK cells. One of the best known activating receptors is NKG2D, a member of the CD94/NKG2 family. Due to a specific NKG2D binding with its eight different ligands, which are overexpressed in transformed, infected and stressed cells, NK cells are able to recognize and attack their targets. The NKG2D receptor has an enormous significance in various, autoimmune diseases, viral and bacterial infections as well as for transplantation outcomes and complications. This review focuses on the NKG2D receptor, the mechanism of its action, clinical relevance of its gene polymorphisms and a potential application in various clinical settings.

Keywords

NKG2D receptor;NKG2D ligands;NK cells

Authors

SIEMASZKO, J.; MARZEC-PRZYSZLAK, A.; BOGUNIA-KUBIK, K.

Released

7. 6. 2021

Publisher

MDPI

ISBN

2073-4409

Periodical

Cells

Year of study

10

Number

6

State

Swiss Confederation

URL

https://www.mdpi.com/2073-4409/10/6/1420

BibTex

@article{BUT183140,
  author="Jagoda {Siemaszko} and Aleksandra {Marzec-Przyszlak} and Katarzyna {Bogunia-Kubik}",
  title="NKG2D Natural Killer Cell Receptor-A Short Description and Potential Clinical Applications",
  journal="Cells",
  year="2021",
  volume="10",
  number="6",
  doi="10.3390/cells10061420",
  issn="2073-4409",
  url="https://www.mdpi.com/2073-4409/10/6/1420"
}