Detail publikace

NKG2D Natural Killer Cell Receptor-A Short Description and Potential Clinical Applications

SIEMASZKO, J. MARZEC-PRZYSZLAK, A. BOGUNIA-KUBIK, K.

Originální název

NKG2D Natural Killer Cell Receptor-A Short Description and Potential Clinical Applications

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Natural Killer (NK) cells are natural cytotoxic, effector cells of the innate immune system. They can recognize transformed or infected cells. NK cells are armed with a set of activating and inhibitory receptors which are able to bind to their ligands on target cells. The right balance between expression and activation of those receptors is fundamental for the proper functionality of NK cells. One of the best known activating receptors is NKG2D, a member of the CD94/NKG2 family. Due to a specific NKG2D binding with its eight different ligands, which are overexpressed in transformed, infected and stressed cells, NK cells are able to recognize and attack their targets. The NKG2D receptor has an enormous significance in various, autoimmune diseases, viral and bacterial infections as well as for transplantation outcomes and complications. This review focuses on the NKG2D receptor, the mechanism of its action, clinical relevance of its gene polymorphisms and a potential application in various clinical settings.

Klíčová slova

NKG2D receptor;NKG2D ligands;NK cells

Autoři

SIEMASZKO, J.; MARZEC-PRZYSZLAK, A.; BOGUNIA-KUBIK, K.

Vydáno

7. 6. 2021

Nakladatel

MDPI

ISSN

2073-4409

Periodikum

Cells

Ročník

10

Číslo

6

Stát

Švýcarská konfederace

URL

https://www.mdpi.com/2073-4409/10/6/1420

BibTex

@article{BUT183140,
  author="Jagoda {Siemaszko} and Aleksandra {Marzec-Przyszlak} and Katarzyna {Bogunia-Kubik}",
  title="NKG2D Natural Killer Cell Receptor-A Short Description and Potential Clinical Applications",
  journal="Cells",
  year="2021",
  volume="10",
  number="6",
  doi="10.3390/cells10061420",
  issn="2073-4409",
  url="https://www.mdpi.com/2073-4409/10/6/1420"
}