Publication detail

Relative entropy is an easy-to-use invasive electroencephalographic biomarker of the epileptogenic zone

TRÁVNÍČEK, V. KLIMEŠ, P. CIMBÁLNÍK, J. HALÁMEK, J. JURÁK, P. BRINKMANN, B. BALZEKAS, I. ABDOULAH, C. DUBEAU, F. WORRELL, G. BRÁZDIL, M.

Original Title

Relative entropy is an easy-to-use invasive electroencephalographic biomarker of the epileptogenic zone

Type

journal article in Web of Science

Language

English

Original Abstract

Objective: High-frequency oscillations are considered among the most promising interictal biomarkers of the epileptogenic zone in patients suffering from pharmacoresistant focal epilepsy. However, there is no clear definition of pathological high-frequency oscillations, and the existing detectors vary in methodology, performance, and computational costs. This study proposes relative entropy as an easy-to-use novel interictal biomarker of the epileptic tissue.Methods: We evaluated relative entropy and high-frequency oscillation biomarkers on intracranial electroencephalographic data from 39 patients with seizure-free postoperative outcome (Engel Ia) from three institutions. We tested their capability to localize the epileptogenic zone, defined as resected contacts located in the seizure onset zone. The performance was compared using areas under the receiver operating curves (AUROCs) and precision-recall curves. Then we tested whether a universal threshold can be used to delineate the epileptogenic zone across patients from different institutions.Results: Relative entropy in the ripple band (80-250 Hz) achieved an average AUROC of .85. The normalized high-frequency oscillation rate in the ripple band showed an identical AUROC of .85. In contrast to high-frequency oscillations, relative entropy did not require any patient-level normalization and was easy and fast to calculate due to its clear and straightforward definition. One threshold could be set across different patients and institutions, because relative entropy is independent of signal amplitude and sampling frequency.Significance: Although both relative entropy and high-frequency oscillations have a similar performance, relative entropy has significant advantages such as straightforward definition, computational speed, and universal interpatient threshold, making it an easy-to-use promising biomarker of the epileptogenic zone.

Keywords

drug-resistant epilepsy; iEEG; SOZ localization

Authors

TRÁVNÍČEK, V.; KLIMEŠ, P.; CIMBÁLNÍK, J.; HALÁMEK, J.; JURÁK, P.; BRINKMANN, B.; BALZEKAS, I.; ABDOULAH, C.; DUBEAU, F.; WORRELL, G.; BRÁZDIL, M.

Released

10. 2. 2023

Publisher

WILEY

Location

HOBOKEN

ISBN

0013-9580

Periodical

EPILEPSIA

Year of study

64

Number

4

State

United States of America

Pages from

962

Pages to

972

Pages count

11

URL

https://onlinelibrary.wiley.com/doi/10.1111/epi17539

BibTex

@article{BUT184402,
  author="Vojtěch {Trávníček} and Petr {Klimeš} and Jan {Cimbálník} and Josef {Halámek} and Pavel {Jurák} and Benjamin H. {Brinkmann} and Irena {Balzekas} and Chifaou {Abdoulah} and Francois {Dubeau} and Gregory {Worrell} and Milan {Brázdil}",
  title="Relative entropy is an easy-to-use invasive electroencephalographic biomarker of the epileptogenic zone",
  journal="EPILEPSIA",
  year="2023",
  volume="64",
  number="4",
  pages="962--972",
  doi="10.1111/epi.17539",
  issn="0013-9580",
  url="https://onlinelibrary.wiley.com/doi/10.1111/epi17539"
}