Publication detail

c-Jun N-terminal kinase signaling in cellular senescence

DENG, Y. ADAM, V. NEPOVIMOVÁ, E. HEGER, Z. VALKO, M. WU, Q. WEI, W. KUČA, K.

Original Title

c-Jun N-terminal kinase signaling in cellular senescence

Type

journal article in Web of Science

Language

English

Original Abstract

Cellular senescence leads to decreased tissue regeneration and inflammation and is associated with diabetes, neurodegenerative diseases, and tumorigenesis. However, the mechanisms of cellular senescence are not fully understood. Emerging evidence has indicated that c-Jun N-terminal kinase (JNK) signaling is involved in the regulation of cellular senescence. JNK can downregulate hypoxia inducible factor-1 alpha to accelerate hypoxia-induced neuronal cell senescence. The activation of JNK inhibits mTOR activity and triggers autophagy, which promotes cellular senescence. JNK can upregulate the expression of p53 and Bcl-2 and accelerates cancer cell senescence; however, this signaling also mediates the expression of amphiregulin and PD-LI to achieve cancer cell immune evasion and prevents their senescence. The activation of JNK further triggers forkhead box O expression and its target gene Jafrac1 to extend the lifespan of Drosophila. JNK can also upregulate the expression of DNA repair protein poly ADP-ribose polymerase 1 and heat shock protein to delay cellular senescence. This review discusses recent advances in understanding the function of JNK signaling in cellular senescence and includes a comprehensive analysis of the molecular mechanisms underlying JNK-mediated senescence evasion and oncogene-induced cellular senescence. We also summarize the research progress in anti-aging agents that target JNK signaling. This study will contribute to a better understanding of the molecular targets of cellular senescence and provides insights into anti-aging, which may be used to develop drugs for the treatment of aging-related diseases.

Keywords

JNK; Cell senescence; Hypoxia; PARP1; Anti-aging

Authors

DENG, Y.; ADAM, V.; NEPOVIMOVÁ, E.; HEGER, Z.; VALKO, M.; WU, Q.; WEI, W.; KUČA, K.

Released

1. 8. 2023

Publisher

SPRINGER HEIDELBERG

Location

HEIDELBERG

ISBN

1432-0738

Periodical

Archives of Toxicology

Year of study

97

Number

8

State

Federal Republic of Germany

Pages from

2089

Pages to

2109

Pages count

21

URL

https://link.springer.com/article/10.1007/s00204-023-03540-1

BibTex

@article{BUT184927,
  author="DENG, Y. and ADAM, V. and NEPOVIMOVÁ, E. and HEGER, Z. and VALKO, M. and WU, Q. and WEI, W. and KUČA, K.",
  title="c-Jun N-terminal kinase signaling in cellular senescence",
  journal="Archives of Toxicology",
  year="2023",
  volume="97",
  number="8",
  pages="2089--2109",
  doi="10.1007/s00204-023-03540-1",
  issn="1432-0738",
  url="https://link.springer.com/article/10.1007/s00204-023-03540-1"
}