Detail publikace

c-Jun N-terminal kinase signaling in cellular senescence

DENG, Y. ADAM, V. NEPOVIMOVÁ, E. HEGER, Z. VALKO, M. WU, Q. WEI, W. KUČA, K.

Originální název

c-Jun N-terminal kinase signaling in cellular senescence

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Cellular senescence leads to decreased tissue regeneration and inflammation and is associated with diabetes, neurodegenerative diseases, and tumorigenesis. However, the mechanisms of cellular senescence are not fully understood. Emerging evidence has indicated that c-Jun N-terminal kinase (JNK) signaling is involved in the regulation of cellular senescence. JNK can downregulate hypoxia inducible factor-1 alpha to accelerate hypoxia-induced neuronal cell senescence. The activation of JNK inhibits mTOR activity and triggers autophagy, which promotes cellular senescence. JNK can upregulate the expression of p53 and Bcl-2 and accelerates cancer cell senescence; however, this signaling also mediates the expression of amphiregulin and PD-LI to achieve cancer cell immune evasion and prevents their senescence. The activation of JNK further triggers forkhead box O expression and its target gene Jafrac1 to extend the lifespan of Drosophila. JNK can also upregulate the expression of DNA repair protein poly ADP-ribose polymerase 1 and heat shock protein to delay cellular senescence. This review discusses recent advances in understanding the function of JNK signaling in cellular senescence and includes a comprehensive analysis of the molecular mechanisms underlying JNK-mediated senescence evasion and oncogene-induced cellular senescence. We also summarize the research progress in anti-aging agents that target JNK signaling. This study will contribute to a better understanding of the molecular targets of cellular senescence and provides insights into anti-aging, which may be used to develop drugs for the treatment of aging-related diseases.

Klíčová slova

JNK; Cell senescence; Hypoxia; PARP1; Anti-aging

Autoři

DENG, Y.; ADAM, V.; NEPOVIMOVÁ, E.; HEGER, Z.; VALKO, M.; WU, Q.; WEI, W.; KUČA, K.

Vydáno

1. 8. 2023

Nakladatel

SPRINGER HEIDELBERG

Místo

HEIDELBERG

ISSN

1432-0738

Periodikum

Archives of Toxicology

Ročník

97

Číslo

8

Stát

Spolková republika Německo

Strany od

2089

Strany do

2109

Strany počet

21

URL

https://link.springer.com/article/10.1007/s00204-023-03540-1

BibTex

@article{BUT184927,
  author="DENG, Y. and ADAM, V. and NEPOVIMOVÁ, E. and HEGER, Z. and VALKO, M. and WU, Q. and WEI, W. and KUČA, K.",
  title="c-Jun N-terminal kinase signaling in cellular senescence",
  journal="Archives of Toxicology",
  year="2023",
  volume="97",
  number="8",
  pages="2089--2109",
  doi="10.1007/s00204-023-03540-1",
  issn="1432-0738",
  url="https://link.springer.com/article/10.1007/s00204-023-03540-1"
}