Publication detail

Organotin(IV)-Decorated Graphene Quantum Dots as Dual Platform for Molecular Imaging and Treatment of Triple Negative Breast Cancer

GOMEZ PEREZ, I. OVEJERO-PAREDES, K. MENDEZ-ARRIAGA, J. PIZÚROVÁ, N. FILICE, M. ZAJÍČKOVÁ, L. PRASHAR, S. GOMEZ-RUIZ, S.

Original Title

Organotin(IV)-Decorated Graphene Quantum Dots as Dual Platform for Molecular Imaging and Treatment of Triple Negative Breast Cancer

Type

journal article in Web of Science

Language

English

Original Abstract

The pharmacological activity of organotin(IV) complexes in cancer therapy is well recognized but their large applicability is hampered by their poor water solubility. Hence, carbon dots, in particular nitrogen-doped graphene quantum dots (NGQDs), may be a promising alternative for the efficient delivery of organotin(IV) compounds as they have a substantial aqueous solubility, a good chemical stability, and non-toxicity as well as a bright photoluminescence that make them ideal for theranostic applications against cancer. Two different multifunctional nanosystems have been synthesized and fully characterized based on two fragments of organotin-based cytotoxic compounds and 4-formylbenzoic acid (FBA), covalently grafted onto the NGQDs surface. Subsequently, an in vitro determination of the therapeutic and theranostic potential of the achieved multifunctional systems was carried out. The results showed a high cytotoxic potential of the NGQDs-FBA-Sn materials against breast cancer cell line (MDA-MB-231) and a lower effect on a non-cancer cell line (kidney cells, HEK293T). Besides, thanks to their optical properties, the dots enabled their fluorescence molecular imaging in the cytoplasmatic region of the cells pointing towards a successful cellular uptake and a release of the metallodrug inside cancer cells (NGQDs-FBA-Sn). Nitrogen-doped graphene quantum dots (NGQDs) have potential for delivering organotin(IV) compounds in cancer therapy due to their water solubility, stability, non-toxicity, and photoluminescence. Two nanosystems were developed by grafting organotin fragments and 4-formylbenzoic acid onto NGQDs. In vitro tests demonstrated high cytotoxicity against breast cancer cells (MDA-MB-231) and minimal effects on non-cancer cells (HEK293T), with successful uptake and release of the metallodrug in cancer cells.image

Keywords

biomedical molecular imaging; graphene quantum dots; metallodrugs; organotin; theranostic

Authors

GOMEZ PEREZ, I.; OVEJERO-PAREDES, K.; MENDEZ-ARRIAGA, J.; PIZÚROVÁ, N.; FILICE, M.; ZAJÍČKOVÁ, L.; PRASHAR, S.; GOMEZ-RUIZ, S.

Released

26. 10. 2023

Publisher

WILEY-V C H VERLAG GMBH

Location

WEINHEIM

ISBN

1521-3765

Periodical

Chemistry - A European Journal

Year of study

29

Number

60

State

Federal Republic of Germany

Pages count

8

URL

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202301845

BibTex

@article{BUT187365,
  author="Inmaculada Jennifer {Gomez Perez} and Karina {Ovejero-Paredes} and Jose Manuel {Mendez-Arriaga} and Naděžda {Pizúrová} and Marco {Filice} and Lenka {Zajíčková} and Sanjiv {Prashar} and Santiago {Gomez-Ruiz}",
  title="Organotin(IV)-Decorated Graphene Quantum Dots as Dual Platform for Molecular Imaging and Treatment of Triple Negative Breast Cancer",
  journal="Chemistry - A European Journal",
  year="2023",
  volume="29",
  number="60",
  pages="8",
  doi="10.1002/chem.202301845",
  issn="1521-3765",
  url="https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202301845"
}