Detail publikace

Organotin(IV)-Decorated Graphene Quantum Dots as Dual Platform for Molecular Imaging and Treatment of Triple Negative Breast Cancer

GOMEZ PEREZ, I. OVEJERO-PAREDES, K. MENDEZ-ARRIAGA, J. PIZÚROVÁ, N. FILICE, M. ZAJÍČKOVÁ, L. PRASHAR, S. GOMEZ-RUIZ, S.

Originální název

Organotin(IV)-Decorated Graphene Quantum Dots as Dual Platform for Molecular Imaging and Treatment of Triple Negative Breast Cancer

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

The pharmacological activity of organotin(IV) complexes in cancer therapy is well recognized but their large applicability is hampered by their poor water solubility. Hence, carbon dots, in particular nitrogen-doped graphene quantum dots (NGQDs), may be a promising alternative for the efficient delivery of organotin(IV) compounds as they have a substantial aqueous solubility, a good chemical stability, and non-toxicity as well as a bright photoluminescence that make them ideal for theranostic applications against cancer. Two different multifunctional nanosystems have been synthesized and fully characterized based on two fragments of organotin-based cytotoxic compounds and 4-formylbenzoic acid (FBA), covalently grafted onto the NGQDs surface. Subsequently, an in vitro determination of the therapeutic and theranostic potential of the achieved multifunctional systems was carried out. The results showed a high cytotoxic potential of the NGQDs-FBA-Sn materials against breast cancer cell line (MDA-MB-231) and a lower effect on a non-cancer cell line (kidney cells, HEK293T). Besides, thanks to their optical properties, the dots enabled their fluorescence molecular imaging in the cytoplasmatic region of the cells pointing towards a successful cellular uptake and a release of the metallodrug inside cancer cells (NGQDs-FBA-Sn). Nitrogen-doped graphene quantum dots (NGQDs) have potential for delivering organotin(IV) compounds in cancer therapy due to their water solubility, stability, non-toxicity, and photoluminescence. Two nanosystems were developed by grafting organotin fragments and 4-formylbenzoic acid onto NGQDs. In vitro tests demonstrated high cytotoxicity against breast cancer cells (MDA-MB-231) and minimal effects on non-cancer cells (HEK293T), with successful uptake and release of the metallodrug in cancer cells.image

Klíčová slova

biomedical molecular imaging; graphene quantum dots; metallodrugs; organotin; theranostic

Autoři

GOMEZ PEREZ, I.; OVEJERO-PAREDES, K.; MENDEZ-ARRIAGA, J.; PIZÚROVÁ, N.; FILICE, M.; ZAJÍČKOVÁ, L.; PRASHAR, S.; GOMEZ-RUIZ, S.

Vydáno

26. 10. 2023

Nakladatel

WILEY-V C H VERLAG GMBH

Místo

WEINHEIM

ISSN

1521-3765

Periodikum

Chemistry - A European Journal

Ročník

29

Číslo

60

Stát

Spolková republika Německo

Strany počet

8

URL

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202301845

BibTex

@article{BUT187365,
  author="Inmaculada Jennifer {Gomez Perez} and Karina {Ovejero-Paredes} and Jose Manuel {Mendez-Arriaga} and Naděžda {Pizúrová} and Marco {Filice} and Lenka {Zajíčková} and Sanjiv {Prashar} and Santiago {Gomez-Ruiz}",
  title="Organotin(IV)-Decorated Graphene Quantum Dots as Dual Platform for Molecular Imaging and Treatment of Triple Negative Breast Cancer",
  journal="Chemistry - A European Journal",
  year="2023",
  volume="29",
  number="60",
  pages="8",
  doi="10.1002/chem.202301845",
  issn="1521-3765",
  url="https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202301845"
}