Publication detail

Nanoformulation of the Broad-Spectrum Hydrophobic Antiviral Vacuolar ATPase Inhibitor Diphyllin in Human Recombinant H-ferritin

VOJNÍKOVÁ, M. SÚKUPOVÁ, M. ŠTEFÁNIK, M. STRAKOVÁ, P. HAVIERNIK, J. KAPOLKOVÁ, K. GRUBEROVÁ, E. RAŠKOVÁ, K. MICHÁLKOVÁ, H. ŠVEC, P. PEŠKOVÁ, M. HUVAROVÁ, I. RŮŽEK, D. SALÁT, J. PEKAŘÍK, V. EYER, L. HEGER, Z.

Original Title

Nanoformulation of the Broad-Spectrum Hydrophobic Antiviral Vacuolar ATPase Inhibitor Diphyllin in Human Recombinant H-ferritin

Type

journal article in Web of Science

Language

English

Original Abstract

As highlighted by recent pandemic outbreaks, antiviral drugs are crucial resources in the global battle against viral diseases. Unfortunately, most antiviral drugs are characterized by a plethora of side effects and low efficiency/poor bioavailability owing to their insolubility. This also applies to the arylnaphthalide lignin family member, diphyllin (Diph). Diph acts as a vacuolar ATPase inhibitor and has been previously identified as a promising candidate with broad-spectrum antiviral activity. However, its physicochemical properties preclude its efficient administration in vivo, complicating preclinical testing.

Keywords

drug delivery, SARS-CoV-2, TBEV, WNV, Zika virus

Authors

VOJNÍKOVÁ, M.; SÚKUPOVÁ, M.; ŠTEFÁNIK, M.; STRAKOVÁ, P.; HAVIERNIK, J.; KAPOLKOVÁ, K.; GRUBEROVÁ, E.; RAŠKOVÁ, K.; MICHÁLKOVÁ, H.; ŠVEC, P.; PEŠKOVÁ, M.; HUVAROVÁ, I.; RŮŽEK, D.; SALÁT, J.; PEKAŘÍK, V.; EYER, L.; HEGER, Z.

Released

30. 4. 2024

ISBN

1178-2013

Periodical

International Journal of Nanomedicine

Number

19

State

New Zealand

Pages from

3907

Pages to

3917

Pages count

11

URL

https://www.dovepress.com/nanoformulation-of-the-broad-spectrum-hydrophobic-antiviral-vacuolar-a-peer-reviewed-fulltext-article-IJN

BibTex

@article{BUT188515,
  author="Michaela {Vojníková} and Martina {Súkupová} and Michal {Štefánik} and Petra {Straková} and Jan {Haviernik} and Kateřina {Kapolková} and Eliška {Gruberová} and Klára {Rašková} and Hana {Michálková} and Pavel {Švec} and Marie {Pešková} and Ivana {Huvarová} and Daniel {Růžek} and Jiří {Salát} and Vladimír {Pekařík} and Luděk {Eyer} and Zbyněk {Heger}",
  title="Nanoformulation of the Broad-Spectrum Hydrophobic Antiviral Vacuolar ATPase Inhibitor Diphyllin in Human Recombinant H-ferritin",
  journal="International Journal of Nanomedicine",
  year="2024",
  number="19",
  pages="3907--3917",
  doi="10.2147/IJN.S452119",
  issn="1178-2013",
  url="https://www.dovepress.com/nanoformulation-of-the-broad-spectrum-hydrophobic-antiviral-vacuolar-a-peer-reviewed-fulltext-article-IJN"
}