Detail publikace

Nanoformulation of the Broad-Spectrum Hydrophobic Antiviral Vacuolar ATPase Inhibitor Diphyllin in Human Recombinant H-ferritin

VOJNÍKOVÁ, M. SÚKUPOVÁ, M. ŠTEFÁNIK, M. STRAKOVÁ, P. HAVIERNIK, J. KAPOLKOVÁ, K. GRUBEROVÁ, E. RAŠKOVÁ, K. MICHÁLKOVÁ, H. ŠVEC, P. PEŠKOVÁ, M. HUVAROVÁ, I. RŮŽEK, D. SALÁT, J. PEKAŘÍK, V. EYER, L. HEGER, Z.

Originální název

Nanoformulation of the Broad-Spectrum Hydrophobic Antiviral Vacuolar ATPase Inhibitor Diphyllin in Human Recombinant H-ferritin

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

As highlighted by recent pandemic outbreaks, antiviral drugs are crucial resources in the global battle against viral diseases. Unfortunately, most antiviral drugs are characterized by a plethora of side effects and low efficiency/poor bioavailability owing to their insolubility. This also applies to the arylnaphthalide lignin family member, diphyllin (Diph). Diph acts as a vacuolar ATPase inhibitor and has been previously identified as a promising candidate with broad-spectrum antiviral activity. However, its physicochemical properties preclude its efficient administration in vivo, complicating preclinical testing.

Klíčová slova

drug delivery, SARS-CoV-2, TBEV, WNV, Zika virus

Autoři

VOJNÍKOVÁ, M.; SÚKUPOVÁ, M.; ŠTEFÁNIK, M.; STRAKOVÁ, P.; HAVIERNIK, J.; KAPOLKOVÁ, K.; GRUBEROVÁ, E.; RAŠKOVÁ, K.; MICHÁLKOVÁ, H.; ŠVEC, P.; PEŠKOVÁ, M.; HUVAROVÁ, I.; RŮŽEK, D.; SALÁT, J.; PEKAŘÍK, V.; EYER, L.; HEGER, Z.

Vydáno

30. 4. 2024

ISSN

1178-2013

Periodikum

International Journal of Nanomedicine

Číslo

19

Stát

Nový Zéland

Strany od

3907

Strany do

3917

Strany počet

11

URL

https://www.dovepress.com/nanoformulation-of-the-broad-spectrum-hydrophobic-antiviral-vacuolar-a-peer-reviewed-fulltext-article-IJN

BibTex

@article{BUT188515,
  author="Michaela {Vojníková} and Martina {Súkupová} and Michal {Štefánik} and Petra {Straková} and Jan {Haviernik} and Kateřina {Kapolková} and Eliška {Gruberová} and Klára {Rašková} and Hana {Michálková} and Pavel {Švec} and Marie {Pešková} and Ivana {Huvarová} and Daniel {Růžek} and Jiří {Salát} and Vladimír {Pekařík} and Luděk {Eyer} and Zbyněk {Heger}",
  title="Nanoformulation of the Broad-Spectrum Hydrophobic Antiviral Vacuolar ATPase Inhibitor Diphyllin in Human Recombinant H-ferritin",
  journal="International Journal of Nanomedicine",
  year="2024",
  number="19",
  pages="3907--3917",
  doi="10.2147/IJN.S452119",
  issn="1178-2013",
  url="https://www.dovepress.com/nanoformulation-of-the-broad-spectrum-hydrophobic-antiviral-vacuolar-a-peer-reviewed-fulltext-article-IJN"
}