Publication detail

Advanced Lipid-Based Nanotransporters for Encapsulation of Cytochrome C

MARÁKOVÁ, E. VOJNÍKOVÁ, M. MILLER, A. GRUBEROVÁ, E. HEGER, Z.

Original Title

Advanced Lipid-Based Nanotransporters for Encapsulation of Cytochrome C

Type

conference paper

Language

English

Original Abstract

Therapeutic proteins are an exciting and growing, yet complicated research area. Achieving any therapeutic success can be an issue, mainly due to their short half-life, low permeation and possible immunogenicity. Therefore, to overcome these challenges, the aim of this project is to develop a pH-sensitive liposomes (LNPs) suitable for cytochrome c encapsulation. Cytochrome c is a relatively small protein with a molecular weight of about 12 kDa. It is located in mitochondria and is mostly known as an electron carrier between complexes III and IV of the respiratory chain. However, cytochrome c is a protein with a dual function. In the presence of the right stimuli, cytochrome c is released from mitochondria in a process called mitochondrial outer membrane permeabilisation, which in turn induces apoptosis.

Keywords

cytochrome c, ferritin, drug-delivery, nanomedicine

Authors

MARÁKOVÁ, E.; VOJNÍKOVÁ, M.; MILLER, A.; GRUBEROVÁ, E.; HEGER, Z.

Released

8. 4. 2024

Publisher

INTERNATIONAL ASET INC. – ALL

Location

London

ISBN

9781990800337

Book

Proceedings of the 9th World Congress on Recent Advances in Nanotechnology

Pages count

2

BibTex

@inproceedings{BUT188542,
  author="Ester {Maráková} and Michaela {Vojníková} and Andrew David {Miller} and Eliška {Gruberová} and Zbyněk {Heger}",
  title="Advanced Lipid-Based Nanotransporters for Encapsulation of Cytochrome C",
  booktitle="Proceedings of the 9th World Congress on Recent Advances in Nanotechnology",
  year="2024",
  pages="2",
  publisher="INTERNATIONAL ASET INC. – ALL",
  address="London",
  doi="10.11159/NDDTE24.143",
  isbn="9781990800337"
}