Detail publikace

Advanced Lipid-Based Nanotransporters for Encapsulation of Cytochrome C

MARÁKOVÁ, E. VOJNÍKOVÁ, M. MILLER, A. GRUBEROVÁ, E. HEGER, Z.

Originální název

Advanced Lipid-Based Nanotransporters for Encapsulation of Cytochrome C

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

Therapeutic proteins are an exciting and growing, yet complicated research area. Achieving any therapeutic success can be an issue, mainly due to their short half-life, low permeation and possible immunogenicity. Therefore, to overcome these challenges, the aim of this project is to develop a pH-sensitive liposomes (LNPs) suitable for cytochrome c encapsulation. Cytochrome c is a relatively small protein with a molecular weight of about 12 kDa. It is located in mitochondria and is mostly known as an electron carrier between complexes III and IV of the respiratory chain. However, cytochrome c is a protein with a dual function. In the presence of the right stimuli, cytochrome c is released from mitochondria in a process called mitochondrial outer membrane permeabilisation, which in turn induces apoptosis.

Klíčová slova

cytochrome c, ferritin, drug-delivery, nanomedicine

Autoři

MARÁKOVÁ, E.; VOJNÍKOVÁ, M.; MILLER, A.; GRUBEROVÁ, E.; HEGER, Z.

Vydáno

8. 4. 2024

Nakladatel

INTERNATIONAL ASET INC. – ALL

Místo

London

ISBN

9781990800337

Kniha

Proceedings of the 9th World Congress on Recent Advances in Nanotechnology

Strany počet

2

BibTex

@inproceedings{BUT188542,
  author="Ester {Maráková} and Michaela {Vojníková} and Andrew David {Miller} and Eliška {Gruberová} and Zbyněk {Heger}",
  title="Advanced Lipid-Based Nanotransporters for Encapsulation of Cytochrome C",
  booktitle="Proceedings of the 9th World Congress on Recent Advances in Nanotechnology",
  year="2024",
  pages="2",
  publisher="INTERNATIONAL ASET INC. – ALL",
  address="London",
  doi="10.11159/NDDTE24.143",
  isbn="9781990800337"
}