Publication detail

Interictal invasive very high-frequency oscillations in resting awake state and sleep

TRÁVNÍČEK, V. REVAJOVÁ, K. HALÁMEK, J. PAIL, M.

Original Title

Interictal invasive very high-frequency oscillations in resting awake state and sleep

Type

journal article in Web of Science

Language

English

Original Abstract

Interictal very high-frequency oscillations (VHFOs, 500-2000 Hz) in a resting awake state seem to be, according to a precedent study of our team, a more specific predictor of a good outcome of the epilepsy surgery compared to traditional interictal high-frequency oscillations (HFOs, 80-500 Hz). In this study, we retested this hypothesis on a larger cohort of patients. In addition, we also collected patients' sleep data and hypothesized that the occurrence of VHFOs in sleep will be greater than in resting state. We recorded interictal invasive electroencephalographic (iEEG) oscillations in 104 patients with drug-resistant epilepsy in a resting state and in 35 patients during sleep. 21 patients in the rest study and 11 patients in the sleep study met the inclusion criteria (interictal HFOs and VHFOs present in iEEG recordings, a surgical intervention and a postoperative follow-up of at least 1 year) for further evaluation of iEEG data. In the rest study, patients with good postoperative outcomes had significantly higher ratio of resected contacts with VHFOs compared to HFOs. In sleep, VHFOs were more abundant than in rest and the percentage of resected contacts in patients with good and poor outcomes did not considerably differ in any type of oscillations. In conclusion, (1) our results confirm, in a larger patient cohort, our previous work about VHFOs being a specific predictor of the area which needs to be resected; and (2) that more frequent sleep VHFOs do not further improve the results.

Keywords

epilepsy, very high frequency oscillations, EEG

Authors

TRÁVNÍČEK, V.; REVAJOVÁ, K.; HALÁMEK, J.; PAIL, M.

Released

6. 11. 2023

Publisher

NATURE PORTFOLIO

Location

BERLIN

ISBN

2045-2322

Periodical

Scientific Reports

Year of study

13

Number

19225

State

United Kingdom of Great Britain and Northern Ireland

Pages count

11

URL

http://www.nature.com/articles/s41598-023-46024-z

BibTex

@article{BUT189984,
  author="Vojtěch {Trávníček} and Karin {Revajová} and Josef {Halámek} and Martin {Pail}",
  title="Interictal invasive very high-frequency oscillations in resting awake state and sleep",
  journal="Scientific Reports",
  year="2023",
  volume="13",
  number="19225",
  pages="11",
  doi="10.1038/s41598-023-46024-z",
  issn="2045-2322",
  url="http://www.nature.com/articles/s41598-023-46024-z"
}