Course detail

Bioinformatics

FEKT-BPC-BINAcad. year: 2023/2024

The course is oriented to principles of bioinformatic processing of biological sequences. It is focused on getting knowledge about biological databases, their structure, and possibilities of their use. It is focused on the study of information methods used for analysis of sequences from biological databases including DAN and on the study of terms genomics and proteomics. Students will get experimental knowledge using Matlab that will be used for design of algorithms for acquisition and processing of biological sequences.

Language of instruction

Czech

Number of ECTS credits

5

Mode of study

Not applicable.

Entry knowledge

The student should be able to explain fundamental principles of genetics, should know basic terms and laws of molecular biology and should be oriented in basic knowledge of digital signal processing. Generally, knowledge on the level of secondary education is required.

Rules for evaluation and completion of the course

up to 40 points from computer exercises (2 tests and 1 practical work)
up to 60 points from finel written exam
The exam is oriented to verification of orientation in basic terms of bioinformatics, ability to design methods for sequence analysis, apply operations on sequences.
Computer exercises are obligatory. Excused absence can be substituted.

Aims

The aim of the course is to inform students about bioinformatics, namely about information structure in biological databases and way of their use and about methods of analysis of sequences acquired from biological databases.
The student will be able to:
- acquire information from biological databasis,
- explain fundamental terms of bioinformatics,
- describe principle of basic methods for analysis of sequences from biological databases,
- discus advantages and disadvantages of the methods,
- design custom methods for sequence analysis based on defined requirements.

Study aids

Not applicable.

Prerequisites and corequisites

Not applicable.

Basic literature

LESK, Arthur, 2019. Introduction to bioinformatics. Oxford University Press. ISBN 978-019-8794-141 (EN)
PEVSNER, Jonathan, 2015. Bioinformatics and functional genomics. Third edition. Chichester: Wiley-Blackwell. ISBN 978-1-118-58178-0 (EN)

Recommended reading

Not applicable.

Elearning

Classification of course in study plans

  • Programme BPC-BTB Bachelor's 2 year of study, summer semester, compulsory

Type of course unit

 

Lecture

26 hod., optionally

Teacher / Lecturer

Syllabus

1. Úvod do bioinformatiky, základy molekulární biologie
2. Datové formáty využívající se v bioinformatice
3. Základy sekvenace
4. Základy dynamického programování
5. Algoritmy zarovnávání biologických sekvencí 1
6. Mutace a substituční matice
7. BLAST a zarovnávání více sekvencí
8 Fylogenetika a fylogenetické stromy, konstrukce fylogenetických stromů
9. Numerické reprezentace
10. Predikce proteinových struktur.

Exercise in computer lab

26 hod., compulsory

Teacher / Lecturer

Syllabus

1. Úvod do molekulární biologie, opakování základů Pythonu
2. Datové formáty v bioinformatice
3. Práce se sekvenačními daty
4. LCS a editační vzdálenost
5. Globální zarovnávání sekvencí
6. Lokální zarovnávání sekvencí
7. Skórovací a substituční matice
8. Vícenásobné zarovnávání sekvencí, BLAST 
9. Numerické reprezentace
10. Signálové zpracování bioinformatických dat
11. Predikce proteinových struktur
12. Konstrukce fylogenetických stromů

Elearning