Course detail

Molecular Genetics I

FCH-BC_MOG1Acad. year: 2025/2026

History of molecular genetics. Genetic information and the genetic code. Molecular structure of procaryotic and eucaryotic genome. Replication and transcription of procaryotic and eucaryotic genome. Postranscriptional modification and processing of RNA. Translation and posttranslational processing. Regulation of gene expression. Molecular basis of cancerogenesis (oncogenes, antioncogenes). Molecular mechanisms of mutagenesis and recombination. Mobile elements. Repair mechanisms of damaged DNA. Basic methods of molecular genetics. DNA cloning. Gene engineering and transgenic organisms.

Language of instruction

Czech

Number of ECTS credits

4

Mode of study

Not applicable.

Guarantor

Mgr. Jan Smetana, Ph.D.

Department

Institute of Food Science and Biotechnology (ÚCHPBT)

Entry knowledge

The structure and basic functions of living systems, their reproduction, cell chemistry, structure and function of biomacromolecules.

Rules for evaluation and completion of the course

Oral exam
Lectures are optional, no control tests during the semester.

Aims

This lecture is conceived as an introduction into molecular biology and genetics and gives the explanation of processes on molecular level in relation to the basic functions of living systems. The second part of the lecture is focused on basic methods of molecular genetics and their applications in gene engineering which is a main tool of modern biotechnologies.
The basic knowledge of molecular biology, using methods of molecular biology and gene engineering in the research area, in industry, agriculture and medicine.

Study aids

Not applicable.

Prerequisites and corequisites

Not applicable.

Basic literature

Rosypal S. a kol.: Úvod do molekulární biologie. S. Rosypal, Brno 2006. (CS)
Sundstad P., Simmons M.J. Genetika. Český překlad, Masarykova univerzita, Brno 2009 (CS)

Recommended reading

Watson, J.D. et al.: Recombinant DNA, W.H.Freeman, New York 1992. (CS)

Classification of course in study plans

  • Programme BPCP_CHMA Bachelor's 3 year of study, winter semester, compulsory-optional

  • Programme BKCP_CHTP Bachelor's

    specialization CHPL , 3 year of study, winter semester, compulsory-optional
    specialization PCH , 3 year of study, winter semester, compulsory-optional
    specialization BT , 3 year of study, winter semester, compulsory

  • Programme BKCP_CHTPO Bachelor's

    specialization PCH , 3 year of study, winter semester, compulsory-optional
    specialization CHPL , 3 year of study, winter semester, compulsory-optional
    specialization BT , 3 year of study, winter semester, compulsory

  • Programme BPCP_CHTP Bachelor's

    specialization CHPL , 3 year of study, winter semester, compulsory-optional
    specialization PCH , 3 year of study, winter semester, compulsory-optional
    specialization BT , 3 year of study, winter semester, compulsory

  • Programme BPCP_CHTPO Bachelor's

    specialization CHPL , 3 year of study, winter semester, compulsory-optional
    specialization PCH , 3 year of study, winter semester, compulsory-optional
    specialization BT , 3 year of study, winter semester, compulsory

  • Programme MITAI Master's

    specialization NSEC , 0 year of study, winter semester, elective
    specialization NISY up to 2020/21 , 0 year of study, winter semester, elective
    specialization NNET , 0 year of study, winter semester, elective
    specialization NMAL , 0 year of study, winter semester, elective
    specialization NCPS , 0 year of study, winter semester, elective
    specialization NHPC , 0 year of study, winter semester, elective
    specialization NVER , 0 year of study, winter semester, elective
    specialization NIDE , 0 year of study, winter semester, elective
    specialization NISY , 0 year of study, winter semester, elective
    specialization NEMB , 0 year of study, winter semester, elective
    specialization NSPE , 0 year of study, winter semester, elective
    specialization NEMB , 0 year of study, winter semester, elective
    specialization NBIO , 1 year of study, winter semester, compulsory
    specialization NSEN , 0 year of study, winter semester, elective
    specialization NVIZ , 0 year of study, winter semester, elective
    specialization NGRI , 0 year of study, winter semester, elective
    specialization NADE , 0 year of study, winter semester, elective
    specialization NISD , 0 year of study, winter semester, elective
    specialization NMAT , 0 year of study, winter semester, elective

Type of course unit

 

Lecture

26 hod., optionally

Teacher / Lecturer

Mgr. Jan Smetana, Ph.D.

Syllabus

History of molecular genetics. Genetic information and the genetic code. Molecular structure of procaryotic and eucaryotic genome. Replication and transcription of procaryotic and eucaryotic genome. Postranscriptional modification and processing of RNA. Translation and posttranslational processing. Regulation of gene expression. Molecular basis of cancerogenesis (oncogenes, antioncogenes). Molecular mechanisms of mutagenesis and recombination. Mobile elements. Repair mechanisms of damaged DNA. Basic methods of molecular genetics. DNA cloning. Gene engineering and transgenic organisms. Gene therapy. Genetic diseases and their diagnostics. Molecular genetics of plants and their use in agriculture.