The doctoral study provides the graduates of MSc study in the area of biomedical electronics and biocybernetics with a higher degree of education, deepening their theoretical background.
The study is aimed at deepening of theoretical knowledge of students in advanced mathematics, physics and in disciplins forming the theoretical basis of the chosen field. Also, necessary experience in experimental work and in processing of the obtained results should be provided, including exploitation of advanced methods of applied informatics.
The final goal is that the students will master methods of scientific research.

A graduate of the doctoral study is expected to be a distinct personality with a recognised research result, wide horizon of knowledge and ability to solve complex scientific and technical-research tasks in the field of biomedical electronics and biocybernetics and in neighbouring fields.
Maximum flexibility and professional adaptivity is the undisputed property of a graduate of doctoral study.
The graduates of the doctoral study in biomedical electronics and biocybernetics will be capable of working as scientists and researchers involved in basic or applied research namely in medical or biological area, as leading specialists in development and construction departments of research and development institutions, and in manufacturing enterprises or institutions exploiting advanced technology, namely in biomedical field.

Graduate of doctoral programme should be a strong personality with substantial scientific results, large horizon and ability to solve complex scientific and research technical tasks in area of biomedical electronics and biocybernetics. He/she will have maximum flexibility and professional adaptability in wide area of biomedical engineering. Graduates will be able to work as scientific and research staff in basic and applied research, as specialists in development, construction and production, in research institutes and at industrial companies and users of medical devices and applied information technologies in medicine and biology.

prof. Ing. Jiří Jan, CSc.

1. Advanced Methods in MRI Perfusion Analysis

   The project is focused on increased reliability of perfusion imaging using magnetic resonance. It covers development of new acquisition and processing methods applied to dynamic contrast-enhanced MRI sequences with application in oncology. Specifically new methods will be developed which combine the techniques DCE, DSC and ASL. Acquisition methods will be implemented on experiemntal magnetic resonance scanners at Institute of Scientific Instrumentation of the ASCR (4.7T and 9.4T), eventually on a medical system at Masaryk Memorial Cancer Institute (1.5T). Validation wil be done using simulated, preclinical and clinical data.

   Tutor: Jiřík Radovan, doc. Ing., Ph.D.

2. Analysis of Human Electrocardiograms and Electrograms of Experimental Isolated Animal Hearts

   The project will be focused to preprocessing, automated analysis and segmentation of human electrocardiograms and electrograms recorded from hearts of experimental animals using optical system at Medical Faculty of Masaryk University. Analytical part of the project will be focused to development of methods for automated analysis of heart rhythm and QT-intervals in long-term recordings.

   Tutor: Kozumplík Jiří, doc. Ing., CSc.

3. Analysis of multimodal 3D image data for paediatric purposes

   The project concerns processing and analysis of 3D image multimodal data including their time series, particularly aimed at improvement of medical diagnostics support namely of children patients, in cooperation with the Clinic of paediatric radiology (Doc. MUDr. Jarmila Skotáková, CSc) of the Faculty Hospital Brno. Specific properties of the individual imaging modalities (CT, MRI, PET, possibly even US) will be utilised for analysis of the imaged tissues, and providing of medically relevant added information obtained by advanced methods of image analysis and by automatic fusion of these data is expected. The student is supposed to be highly motivated for demanding research work in the interdisciplinary area, and capable of algorithm design and implementation of computer programmes. The project is supposed to be supported by Philips Nederland.

   Tutor: Jan Jiří, prof. Ing., CSc.

4. Bioinformatic studies of results from electrochemical measurement for monitoring RNA and DNA molecules

   The themeis oriented to research on bioinformatic methods for analysis of data from monitoring interactions of small RNA molecules. Studies will cover structural changes and their bahaviour when using various physical-chemical and molecular-biological techniques. The methods will use modern methods of vector representation of genomic sequences, genomic signal processing and measurement of sequence distances. The aim is to design of such methods that allow reliable detection of selected interactions based on analysis of liner sequences of nucleotides of RNA molecules. The work will be supported by grant project GACR "Nano-Electro-Bio-Tools for Biochemical and Molecularly-Biological Studies of Eukaryotic Cells (NanoBioTECell)" from 1.1.2011 to 31.12. 2015 (principal investigator prof. Provazník).

   Tutor: Provazník Valentýna, prof. Ing., Ph.D.

5. Computer aided diagnosis in ophthalmology

   This project is focused on retinal image processing acquired by digital fundus camera. The main aim is to design a methodology for analysis of the time sequences. The used method will include image registration, preprocessing, segmentation and results visualization. The results of the project should improve the retinal pathology diagnosis and evaluation of treatment effects.

   Tutor: Kolář Radim, doc. Ing., Ph.D.

6. Measurement of Transmembrane Cell Potentials with the Use of Fluorescent Dyes

   The theme includes research of new organic indicators of transmembrane potential changes of heart and other myocytes. Indicators will be based on principle of fluorescence with the use of other phenomenons, e.g. "fluorescence resonant energy transfer" (FRET). The aim is to design indicators for microscopic sensing of transmembrane potential changes in real time with effective signal-to-noise ratio and with the possibility of simultaneous measurement at different wavelengths for ratiometric studies. The new indicators will allow measurement of unique data with the use of fast fluorescence digital cameras.

   Tutor: Provazník Valentýna, prof. Ing., Ph.D.

7. Methods for image processing in optical coherence tomography

   This topis deals with optical coherence tomography (OCT) including Doppler, polarization and contrast theory. The research will be focused on the area of processing and analysis of multidimensional OCT images - from preprocessing to deconvolution, segmentation and visualization methods. It will include practical measurment on OCT device followed by processing of acquired data.

   Tutor: Kolář Radim, doc. Ing., Ph.D.

8. Model study of microwave hyperthermia

   Obtained results will contribute to optimization of hyperthermia heating in clinical elimination of tumors.

   Tutor: Rozman Jiří, doc. Ing., CSc.

9. Model study of nonlinear effect in ultrasound diagnostics

   The aim of the PhD. thesis is a model study of nonlinear effects generating higher order harmonic components in ultrasound propagation both in diagnostic and therapeutic applications. The main efforts will be in study, definition and description of ultrasound field nonlinear parameters, energy transfer in the ultrasound signal spectrum and in the application of deterministic chaos theory in describing of studied effects. Ultrasound measurement system at the department will be used in the experimental verification of simulation results.

   Tutor: Rozman Jiří, doc. Ing., CSc.

10. Study of electrical activity of muscles and motion analysis for therapeutic approaches

    The aim of the project is to study the electrical activity of muscles during complex movement therapy. Acquired knowledge of the functional relationship of the muscles and body motion will be used for the design of therapeutic approaches using bio-feedback link. Recording of EMG with the use of clinical devices and recording of motion by cameras will be performed in the project during movement therapy on rehabilitation equipment. The study will be undertaken in collaboration with the medical faculty.

    Tutor: Kolářová Jana, doc. Ing., Ph.D.

11. Study of heart electrophysiology in experimental cardiology

    The aim of the project is heart electrophysiology study and analysis of biosignals recorded from isolated animal heart during experiments. The analysis will be focused on RR and QT intervals detected from electrograms and simultaneously recorded action potentials during global ischemia. Cooperation with faculty of electrophysiology in solving project is supposed.

    Tutor: Kolářová Jana, doc. Ing., Ph.D.