Evropská unie - Horizon 2020

- plně financující (2018-01-01 - 2023-03-28)

759585

angličtina

Adam Vojtěch, prof. RNDr., Ph.D. - hlavní řešitel

Chytré nanonástroje
- příjemce (01.01.2018 - 31.12.2022)
Středoevropský technologický institut VUT
- odpovědné pracoviště (01.01.1989 - 27.08.2020)

MERLOS RODRIGO, M.; BUCHTELOVÁ, H.; DE LOS RIOS, V.; CASAL ÁLVAREZ, J.; ECKSCHLAGER, T.; HRABĚTA, J.; BELHAJOVÁ, M.; HEGER, Z.; ADAM, V. Proteomic signature of neuroblastoma cells UKF-NB-4 reveals key role of lysosomal sequestration and the proteasome complex in acquiring chemoresistance to cisplatin. JOURNAL OF PROTEOME RESEARCH, 2019, vol. 18, no. 3, p. 1255-1263. ISSN: 1535-3893.
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WU, Q.; YOU, L.; NEPOVIMOVÁ, E.; HEGER, Z.; WU, W.; KUČA, K.; ADAM, V. Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape. Journal of Hematology & Oncology, 2022, vol. 15, no. 1, p. 1-18. ISSN: 1756-8722.
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MERLOS RODRIGO, M.; JIMENEZ JIMENEZ, A.; HADDAD, Y.; BODOOR, K.; ADAM, P.; KŘÍŽKOVÁ, S.; HEGER, Z.; ADAM, V. Metallothionein Isoforms as Double Agents - Their Roles in Carcinogenesis, Cancer Progression and Chemoresistance. DRUG RESISTANCE UPDATES, 2020, vol. 52, no. 1, p. 1-13. ISSN: 1368-7646.
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PERIS-DÍAZ, M.; RICHTERA, L.; ZÍTKA, O.; KRĘŻEL, A.; ADAM, V. A chemometric-assisted voltammetric analysis of free and Zn(II)-loaded metallothionein-3 states. BIOELECTROCHEMISTRY, 2020, vol. 134, no. 1, p. 1-8. ISSN: 0302-4598.
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PERIS-DÍAZ, M.; GURÁŇ, R.; ZÍTKA, O.; ADAM, V.; KRĘŻEL, A. Metal- and Affinity-Specific Dual Labeling of Cysteine-Rich Proteins for Identification of Metal-Binding Sites. ANALYTICAL CHEMISTRY, 2020, vol. 92, no. 19, p. 12950-12958. ISSN: 0003-2700.
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PERIS-DÍAZ, M.; GURÁŇ, R.; ZÍTKA, O.; ADAM, V.; KRĘŻEL, A. Mass Spectrometry-Based Structural Analysis of Cysteine-Rich Metal-Binding Sites in Proteins with MetaOdysseus R Software. JOURNAL OF PROTEOME RESEARCH, 2021, vol. 20, no. 1, p. 776-785. ISSN: 1535-3893.
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PAVELICOVÁ, K.; POMPEIANO VANÍČKOVÁ, L.; HADDAD, Y.; NEJDL, L.; ZÍTKA, J.; KOČIOVÁ, S.; MRAVEC, F.; VACULOVIČ, T.; MACKA, M.; VACULOVIČOVÁ, M.; ADAM, V. Metallothionein dimerization evidenced by QD-based Förster resonance energy transfer and capillary electrophoresis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, vol. 170, no. 1, p. 53-60. ISSN: 0141-8130.
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YOU, L.; WU, W.; WANG, X.; FANG, L.; ADAM, V.; NEPOVIMOVÁ, E.; WU, Q.; KUČA, K. The role of hypoxia‐inducible factor 1 in tumor immune evasion. MEDICINAL RESEARCH REVIEWS, 2021, vol. 41, no. 3, p. 1622-1643. ISSN: 0198-6325.
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HAMEDUH, T.; HADDAD, Y.; ADAM, V.; HEGER, Z. Homology modeling in the time of collective and artificial intelligence. Computational and Structural Biotechnology Journal, 2021, vol. 18, no. 1, p. 3494-3506. ISSN: 2001-0370.
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MERLOS RODRIGO, M.; MICHÁLKOVÁ, H.; STRMISKA, V.; CASAR, B.; CRESPO, P.; DE LOS RIOS, V.; CASAL ÁLVAREZ, J.; HADDAD, Y.; GURÁŇ, R.; ECKSCHLAGER, T.; POKORNÁ, P.; HEGER, Z.; ADAM, V. Metallothionein-3 promotes cisplatin chemoresistance remodelling in neuroblastoma. Scientific Reports, 2021, vol. 11, no. 1, p. 1-14. ISSN: 2045-2322.
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ŠTĚPÁNKOVÁ, H.; SWIATKOWSKI, M.; KRUSZYŃSKI, R.; ŠVEC, P.; MICHÁLKOVÁ, H.; SMOLÍKOVÁ, V.; RIDOŠKOVÁ, A.; ŠPLÍCHAL, Z.; MICHÁLEK, P.; RICHTERA, L.; KOPEL, P.; ADAM, V.; HEGER, Z.; REX, S. The Anti-Proliferative Activity of Coordination Compound-Based ZnO Nanoparticles as a Promising Agent Against Triple Negative Breast Cancer Cells. International Journal of Nanomedicine, 2021, vol. 16, no. 1, p. 4431-4449. ISSN: 1178-2013.
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RESSNEROVÁ, A.; NOVOTNÝ, F.; MICHÁLKOVÁ, H.; PUMERA, M.; ADAM, V.; HEGER, Z. Efficient Protein Transfection by Swarms of Chemically Powered Plasmonic Virus-Sized Nanorobots. ACS Nano, 2021, vol. 15, no. 8, p. 12899-12910. ISSN: 1936-0851.
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MERLOS RODRIGO, M.; CASAR, B.; MICHÁLKOVÁ, H.; JIMENEZ JIMENEZ, A.; HEGER, Z.; ADAM, V. Extending the applicability of in ovo and ex ovo chicken chorioallantoic membrane assays to study cytostatic activity in neuroblastoma cells. Frontiers in Oncology, 2021, vol. 11, no. 9, p. 1-10. ISSN: 2234-943X.
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HAMEDUH, T.; MOKRÝ, M.; MILLER, A.; ADAM, V.; HEGER, Z.; HADDAD, Y. A rotamer relay information system in the epidermal growth factor receptor-drug complexes reveals clues to new paradigm in protein conformational change. Computational and Structural Biotechnology Journal, 2021, vol. 19, no. 1, p. 5443-5454. ISSN: 2001-0370.
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PERIS-DÍAZ, M.; GURÁŇ, R.; DOMENE, C.; DE LOS RIOS, V.; ZÍTKA, O.; ADAM, V.; KRĘŻEL, A. An integrated mass spectrometry and molecular dynamics simulations approach reveals the spatial organization impact of metal-binding sites on the stability of metal-depleted metallothionein-2 species. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021, vol. 143, no. 40, p. 16486-16501. ISSN: 0002-7863.
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ZHANG, L.; KUČA, K.; YOU, L.; ZHAO, Y.; MUSÍLEK, K.; NEPOVIMOVÁ, E.; WU, Q.; WU, W.; ADAM, V. Signal Transducer and Activator of Transcription 3 Signaling in Tumor Immune Evasion. PHARMACOLOGY & THERAPEUTICS, 2022, vol. 230, no. 1, p. 1-11. ISSN: 0163-7258.
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HADDAD, Y.; ADAM, V.; HEGER, Z. Rotamer Dynamics: Analysis of Rotamers in Molecular Dynamics Simulations of Proteins. BIOPHYSICAL JOURNAL, 2019, vol. 116, no. 11, p. 2062-2072. ISSN: 0006-3495.
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