Detail publikace

Flow Injection Analysis with Electrochemical Detection for Rapid Identification of Platinum-Based Cytostatics and Platinum Chlorides in Water

KOMÍNKOVÁ, M. HEGER, Z. ZÍTKA, O. KYNICKÝ, J. POHANKA, M. BEKLOVÁ, M. ADAM, V. KIZEK, R.

Originální název

Flow Injection Analysis with Electrochemical Detection for Rapid Identification of Platinum-Based Cytostatics and Platinum Chlorides in Water

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Platinum-based cytostatics, such as cisplatin, carboplatin or oxaliplatin are widely used agents in the treatment of various types of tumors. Large amounts of these drugs are excreted through the urine of patients into wastewaters in unmetabolised forms. This phenomenon leads to increased amounts of platinum ions in the water environment. The impacts of these pollutants on the water ecosystem are not sufficiently investigated as well as their content in water sources. In order to facilitate the detection of various types of platinum, we have developed a new, rapid, screening flow injection analysis method with electrochemical detection (FIA-ED). Our method, based on monitoring of the changes in electrochemical behavior of analytes, maintained by various pH buffers (Britton-Robinson and phosphate buffer) and potential changes (1,000, 1,100 and 1,200 mV) offers rapid and cheap selective determination of platinum-based cytostatics and platinum chlorides, which can also be present as contaminants in water environments.

Klíčová slova

platinum-based cytostatics; platinum chlorides; flow injection analysis with electrochemical detection; hydrodynamic voltammograms

Autoři

KOMÍNKOVÁ, M.; HEGER, Z.; ZÍTKA, O.; KYNICKÝ, J.; POHANKA, M.; BEKLOVÁ, M.; ADAM, V.; KIZEK, R.

Rok RIV

2014

Vydáno

4. 2. 2014

Nakladatel

MDPI

ISSN

1660-4601

Periodikum

International Journal of Environmental Research and Public Health

Ročník

11

Číslo

2

Stát

Švýcarská konfederace

Strany od

1715

Strany do

1724

Strany počet

10

URL

http://www.mdpi.com/1660-4601/11/2/1715

Plný text v Digitální knihovně

http://hdl.handle.net/11012/63718

BibTex

@article{BUT106906,
  author="Markéta {Komínková} and Zbyněk {Heger} and Ondřej {Zítka} and Jindřich {Kynický} and Miroslav {Pohanka} and Miroslava {Beklová} and Vojtěch {Adam} and René {Kizek}",
  title="Flow Injection Analysis with Electrochemical Detection for Rapid Identification of Platinum-Based Cytostatics and Platinum Chlorides in Water",
  journal="International Journal of Environmental Research and Public Health",
  year="2014",
  volume="11",
  number="2",
  pages="1715--1724",
  doi="10.3390/ijerph110201715",
  issn="1660-4601",
  url="http://www.mdpi.com/1660-4601/11/2/1715"
}