Detail publikace

Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and after Chronic Administration of Aripiprazole

DRAŽANOVÁ, E. GROSSOVÁ, L. PISTOVČÁKOVÁ, J. KHAINAR, A. REGINA, D. KAŠPÁREK, T. STARČUK, Z.

Originální název

Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and after Chronic Administration of Aripiprazole

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

Animals prenatally exposed to polyriboinosinic–polyribocytidilic acid (poly I:C) can be used to parallel neuropathological abnormalities seen in schizophrenia patients. The aim of this study was to test the utility of Arterial Spin Labeling (ASL) MRI method for the evaluation of perfusion in different brain regions in the developmental poly I:C model of schizophrenia in rats. In these animals we further investigated the effect of chronic administration of the antipsychotic aripiprazole on brain perfusion. In the circle of Willis region, we observed significant (p<0,05) increase of blood perfusion in the poly I:C model of schizophrenia in both males and females, and significantly higher perfusion in males than in females in vehicle-treated controls. Perfusion in hippocampus (in both hemispheres) was found significantly higher in males than in females in both vehicle-treated controls and poly I:C prenatally exposed animals. The significantly increased blood perfusion in the circle of Willis in poly I:C prenatally exposed males was found to persist even after chronic administration of aripiprazole. These results add new data to understanding of antipsychotic effects and demonstrate the viability of the proposed approach of combination of the ASL MRI method and the selected rat model of schizophrenia.

Klíčová slova

ASL, schizophrenia, poly I:C animal model, rats, aripiprazole

Autoři

DRAŽANOVÁ, E.; GROSSOVÁ, L.; PISTOVČÁKOVÁ, J.; KHAINAR, A.; REGINA, D.; KAŠPÁREK, T.; STARČUK, Z.

Rok RIV

2015

Vydáno

25. 5. 2015

Nakladatel

Institute of Measurement Science

Místo

Bratislava

ISBN

978-80-969672-9-2

Kniha

10th International Conference on Measurement

Strany od

81

Strany do

84

Strany počet

4

URL

http://www.measurement.sk/M2015/

BibTex

@inproceedings{BUT117239,
  author="Eva {Dražanová} and Lucie {Krátká} and Jana {Pistovčáková} and Amit {Khainar} and Demlová {Regina} and Tomáš {Kašpárek} and Zenon {Starčuk}",
  title="Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and after Chronic Administration of Aripiprazole",
  booktitle="10th International Conference on Measurement",
  year="2015",
  pages="81--84",
  publisher="Institute of Measurement Science",
  address="Bratislava",
  isbn="978-80-969672-9-2",
  url="http://www.measurement.sk/M2015/"
}