Detail publikačního výsledku

The Electrochemical Oxidation of Paracetamol and Its Voltammetric Sensing in Biological Samples Based on Screen Printed Graphene Electrodes

FERNANDEZ, C.; HEGER, Z.; KIZEK, R.; RAMAKRISHNAPPA, T.; BORUN, A.; FAISAL, N.

Originální název

The Electrochemical Oxidation of Paracetamol and Its Voltammetric Sensing in Biological Samples Based on Screen Printed Graphene Electrodes

Anglický název

The Electrochemical Oxidation of Paracetamol and Its Voltammetric Sensing in Biological Samples Based on Screen Printed Graphene Electrodes

Druh

Článek WoS

Originální abstrakt

We present a sensitive, fast and unmodified sensor for the electrochemical detection of paracetamol. The electrochemical behaviours of paracetamol on screen printed graphene electrodes were investigated for the first time by cyclic voltammetry. The results showed that the screen printed graphene electrodes revealed exceptional electrocatalytic activity to paracetamol. The response showed by this sensor was enhanced when it was compared to the bare screen printed electrodes. When Screen Printed Graphene Electrodes were compared to bare SPE, it was shown that the response with graphene was greater than without. This is due to its unique characteristics physical and chemical, π-π interactions and a strong adsorptive capability. In this manuscript, the effect of supporting electrolyte, pH and scan rate were also investigated. The oxidation peak current was linearly proportional to the concentration of paracetamol in the range from 0.1 to 50 μM with a limit of detection of 20nM based on (3-σ/slope), under the optimum conditions. The proposed method was successfully applied to paracetamol determination in in biological samples such as human oral fluid.

Anglický abstrakt

We present a sensitive, fast and unmodified sensor for the electrochemical detection of paracetamol. The electrochemical behaviours of paracetamol on screen printed graphene electrodes were investigated for the first time by cyclic voltammetry. The results showed that the screen printed graphene electrodes revealed exceptional electrocatalytic activity to paracetamol. The response showed by this sensor was enhanced when it was compared to the bare screen printed electrodes. When Screen Printed Graphene Electrodes were compared to bare SPE, it was shown that the response with graphene was greater than without. This is due to its unique characteristics physical and chemical, π-π interactions and a strong adsorptive capability. In this manuscript, the effect of supporting electrolyte, pH and scan rate were also investigated. The oxidation peak current was linearly proportional to the concentration of paracetamol in the range from 0.1 to 50 μM with a limit of detection of 20nM based on (3-σ/slope), under the optimum conditions. The proposed method was successfully applied to paracetamol determination in in biological samples such as human oral fluid.

Klíčová slova

Paracetamol; Electrochemical Sensor; Real Samples; Screen Printed Graphene Electrodes

Klíčová slova v angličtině

Paracetamol; Electrochemical Sensor; Real Samples; Screen Printed Graphene Electrodes

Autoři

FERNANDEZ, C.; HEGER, Z.; KIZEK, R.; RAMAKRISHNAPPA, T.; BORUN, A.; FAISAL, N.

Rok RIV

2016

Vydáno

28.07.2015

ISSN

1452-3981

Periodikum

International Journal of Electrochemical Science

Svazek

10

Číslo

9

Stát

Srbská republika

Strany od

7440

Strany do

7452

Strany počet

13

BibTex

@article{BUT118705,
  author="Carlos {Fernandez} and Zbyněk {Heger} and René {Kizek} and Thippeswamy {Ramakrishnappa} and Agnieszka {Borun} and Nadimul {Faisal}",
  title="The Electrochemical Oxidation of Paracetamol and Its Voltammetric Sensing in Biological Samples Based on Screen Printed Graphene Electrodes",
  journal="International Journal of Electrochemical Science",
  year="2015",
  volume="10",
  number="9",
  pages="7440--7452",
  issn="1452-3981"
}