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KOVÁŘ, D. HUBÁLEK, J. FOHLEROVÁ, Z. MALÁ, A. KALINA, M. JIŘÍK, R. STARČUK, Z. SKLÁDAL, P. HLAVÁČEK, A.
Originální název
Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. The citrate-stabilised particles were produced with a narrow average size range below 2 nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI) was then evaluated. The relaxivities and ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising -contrast probe.
Klíčová slova
magnetic nanoparticles, MRI imaging
Autoři
KOVÁŘ, D.; HUBÁLEK, J.; FOHLEROVÁ, Z.; MALÁ, A.; KALINA, M.; JIŘÍK, R.; STARČUK, Z.; SKLÁDAL, P.; HLAVÁČEK, A.
Vydáno
23. 2. 2017
Nakladatel
Hindawi Publishing Corporation
ISSN
1687-4110
Periodikum
JOURNAL OF NANOMATERIALS
Ročník
2017
Číslo
1
Stát
Spojené státy americké
Strany od
Strany do
8
Strany počet
URL
http://dx.doi.org/10.1155/2017/7859289
Plný text v Digitální knihovně
http://hdl.handle.net/11012/68359
BibTex
@article{BUT134091, author="David {Kovář} and Jaromír {Hubálek} and Zdenka {Fohlerová} and Aneta {Malá} and Michal {Kalina} and Radovan {Jiřík} and Antonín {Hlaváček} and Ondřej {Slabý} and Petr {Skládal} and Zdeněk {Farka} and Jitka {Mlčochová} and Zenon {Starčuk jr.}", title="Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging", journal="JOURNAL OF NANOMATERIALS", year="2017", volume="2017", number="1", pages="1--8", doi="10.1155/2017/7859289", issn="1687-4110", url="http://dx.doi.org/10.1155/2017/7859289" }