Detail publikace
G-Quadruplexes as Sensing Probes
RUTTKAY-NEDECKÝ, B. KUDR, J. NEJDL, L. MAŠKOVÁ, D. KIZEK, R. ADAM, V.
Originální název
G-Quadruplexes as Sensing Probes
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
Guanine-rich sequences of DNA are able to create tetrastranded structures known as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding. G-quadruplexes act as ligands for metal ions and aptamers for various molecules. Interestingly, the G-quadruplexes form a complex with anionic porphyrin hemin and exhibit peroxidase-like activity. This review focuses on overview of sensing techniques based on G-quadruplex complexes with anionic porphyrins for detection of various analytes, including metal ions such as K+, Ca2+, Ag+, Hg2+, Cu2+, Pb2+, Sr2+, organic molecules, nucleic acids, and proteins. Principles of G-quadruplex-based detection methods involve DNA conformational change caused by the presence of analyte which leads to a decrease or an increase in peroxidase activity, fluorescence, or electrochemical signal of the used probe. The advantages of various detection techniques are also discussed.
Klíčová slova
G-quadruplex; DNAzyme; hemin
Autoři
RUTTKAY-NEDECKÝ, B.; KUDR, J.; NEJDL, L.; MAŠKOVÁ, D.; KIZEK, R.; ADAM, V.
Vydáno
1. 12. 2013
Nakladatel
MDPI
ISSN
1420-3049
Periodikum
MOLECULES
Ročník
18
Číslo
12
Stát
Švýcarská konfederace
Strany od
14760
Strany do
14779
Strany počet
20
URL
Plný text v Digitální knihovně
BibTex
@article{BUT145126,
author="Branislav {Ruttkay-Nedecký} and Jiří {Kudr} and Lukáš {Nejdl} and Darina {Mašková} and René {Kizek} and Vojtěch {Adam}",
title="G-Quadruplexes as Sensing Probes",
journal="MOLECULES",
year="2013",
volume="18",
number="12",
pages="14760--14779",
doi="10.3390/molecules181214760",
issn="1420-3049",
url="https://www.mdpi.com/1420-3049/18/12/14760"
}