Detail publikace

Impact of Decreased Transmural Conduction Velocity on the Function of the Human Left Ventricle: A Simulation Study

VAVERKA, J. MOUDR, J. LOKAJ, P. BURŠA, J. PÁSEK, M.

Originální název

Impact of Decreased Transmural Conduction Velocity on the Function of the Human Left Ventricle: A Simulation Study

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

This study investigates the impact of reduced transmural conduction velocity (TCV) on output parameters of the human heart. In a healthy heart, the TCV contributes to synchronization of the onset of contraction in individual layers of the left ventricle (LV). However, it is unclear whether the clinically observed decrease of TCV contributes significantly to a reduction of LV contractility. The applied three-dimensional finite element model of isovolumic contraction of the human LV incorporates transmural gradients in electromechanical delay and myocyte shortening velocity and evaluates the impact of TCV reduction on pressure rise (namely, (dP/dt)(max)) and on isovolumic contraction duration (IVCD) in a healthy LV. The model outputs are further exploited in the lumped “Windkessel” model of the human cardiovascular system (based on electrohydrodynamic analogy of respective differential equations) to simulate the impact of changes of (dP/dt)(max) and IVCD on chosen systemic parameters (ejection fraction, LV power, cardiac output, and blood pressure). The simulations have shown that a 50% decrease in TCV prolongs substantially the isovolumic contraction, decelerates slightly the LV pressure rise, increases the LV energy consumption, and reduces the LV power. These negative effects increase progressively with further reduction of TCV. In conclusion, these results suggest that the pumping efficacy of the human LV decreases with lower TCV due to a higher energy consumption and lower LV power. Although the changes induced by the clinically relevant reduction of TCV are not critical for a healthy heart, they may represent an important factor limiting the heart function under disease conditions.

Klíčová slova

heart contraction, left ventricle, finite element model, blood circuit simulation, conduction velocity

Autoři

VAVERKA, J.; MOUDR, J.; LOKAJ, P.; BURŠA, J.; PÁSEK, M.

Vydáno

4. 4. 2020

Nakladatel

Hindawi

Místo

London, United Kingdom

ISSN

2314-6133

Periodikum

BioMed Research International

Ročník

2020

Číslo

1

Stát

Spojené státy americké

Strany od

1

Strany do

11

Strany počet

11

URL

https://www.hindawi.com/journals/bmri/2020/2867865/

Plný text v Digitální knihovně

http://hdl.handle.net/11012/188044

BibTex

@article{BUT163683,
  author="Jiří {Vaverka} and Jiří {Moudr} and Petr {Lokaj} and Jiří {Burša} and Michal {Pásek}",
  title="Impact of Decreased Transmural Conduction Velocity on the Function of the Human Left Ventricle: A Simulation Study",
  journal="BioMed Research International",
  year="2020",
  volume="2020",
  number="1",
  pages="1--11",
  doi="10.1155/2020/2867865",
  issn="2314-6133",
  url="https://www.hindawi.com/journals/bmri/2020/2867865/"
}