Detail publikace

The effect of hydrazide linkers on hyaluronan hydrazone hydrogels

ŠEDOVÁ, P. BUFFA, R. ŠILHÁR, P. KOVÁŘOVÁ, L. VÁGNEROVÁ, H. BEDNAŘÍK, J. BASARABOVÁ, I. HEJLOVÁ, L. ŠČIGALKOVÁ, I. ŠIMEK, M. VELEBNÝ, V.

Originální název

The effect of hydrazide linkers on hyaluronan hydrazone hydrogels

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

The effect of hydrazide linkers on the formation and mechanical properties of hyaluronan hydrogels was intensively evaluated. The reaction kinetics of hydrazone formation was monitored by NMR spectroscopy under physiological conditions where polyaldehyde hyaluronan (unsaturated: Delta HA-CHO, saturated: HA-CHO) was reacted with various hydrazides to form hydrogels. Linear (adipic, oxalic dihydrazide) and branched (N,N',N ''- tris(hexanoylhydrazide-6-yl)phosphoric triamide and 4-arm-PEG hydrazide) hydrazides were compared as crosslinking agents. The mechanical properties of hydrogels were also modified by attaching a hydrophobic chain to HA-CHO; however, it was found that this modification did not lead to an increase in hydrogel stiffness. Cytotoxicity tests showed that all tested hydrazide crosslinkers reduced the viability of cells only slightly, and that the final hyaluronan hydrogels were non-toxic materials.

Klíčová slova

hyaluronan; hydrogel; hydrazone; Schiff base; acylation

Autoři

ŠEDOVÁ, P.; BUFFA, R.; ŠILHÁR, P.; KOVÁŘOVÁ, L.; VÁGNEROVÁ, H.; BEDNAŘÍK, J.; BASARABOVÁ, I.; HEJLOVÁ, L.; ŠČIGALKOVÁ, I.; ŠIMEK, M.; VELEBNÝ, V.

Vydáno

4. 4. 2019

Nakladatel

ELSEVIER SCI LTD

Místo

OXFORD

ISSN

0144-8617

Periodikum

Carbohydrate Polymers

Ročník

216

Číslo

2019

Stát

Spojené království Velké Británie a Severního Irska

Strany od

63

Strany do

71

Strany počet

9

URL

https://pubmed.ncbi.nlm.nih.gov/31047083/

BibTex

@article{BUT165168,
  author="ŠEDOVÁ, P. and BUFFA, R. and ŠILHÁR, P. and KOVÁŘOVÁ, L. and VÁGNEROVÁ, H. and BEDNAŘÍK, J. and BASARABOVÁ, I. and HEJLOVÁ, L. and ŠČIGALKOVÁ, I. and ŠIMEK, M. and VELEBNÝ, V.",
  title="The effect of hydrazide linkers on hyaluronan hydrazone hydrogels",
  journal="Carbohydrate Polymers",
  year="2019",
  volume="216",
  number="2019",
  pages="63--71",
  doi="10.1016/j.carbpol.2019.04.011",
  issn="0144-8617",
  url="https://pubmed.ncbi.nlm.nih.gov/31047083/"
}