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Jakub Věžníka, Martin Konhefra, Zdenka Fohlerová, Karel Lacina
Originální název
Redox-dependent cytotoxicity of ferrocene derivatives and ROS-activated prodrugs based on ferrocenyliminoboronates
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
Four ferrocene derivatives - ferrocenecarboxylic acid, ferrocenium salt, ferroceneboronic acid, and amino-ferrocene - were characterized electrochemically, and their cytotoxicity was probed using cancer cells (line MG -63). We related the observed cytotoxicity with the determined redox potentials of these four ferrocenes - ami-noferrocene with its lowest redox potential exhibited the highest cytotoxicity. Thus, we synthesized four de-rivatives consisting of aminoferrocene and phenylboronic acid residue with the intent to employ them as ROS-activated prodrugs (ROS - reactive oxygen species). We characterized them and studied their time-dependent stability in aqueous environments. Then, we performed electrochemical measurements at oxidative conditions to confirm ROS-responsivity of the synthesized molecules. Finally, the cytotoxicity of the synthesized molecules was tested using cancer MG-63 cells and noncancerous NIH-3T3 cells. The experiments revealed sought behaviour, especially for para-regioisomers of synthesized ferrocenyliminoboronates.
Klíčová slova
Aminoferrocene; Redox-dependent cytotoxicity; ROS-activated prodrugs; Ferrocenyliminoboronates; MG-63; Electrochemical characterization
Autoři
Vydáno
9. 8. 2021
Nakladatel
ELSEVIER SCIENCE INC
Místo
NEW YORK
ISSN
0162-0134
Periodikum
JOURNAL OF INORGANIC BIOCHEMISTRY
Ročník
224
Číslo
1
Stát
Spojené státy americké
Strany od
Strany do
11
Strany počet
8
URL
https://www.sciencedirect.com/science/article/pii/S0162013421002087?via%3Dihub
BibTex
@article{BUT172142, author="Martin {Konhefr} and Zdenka {Fohlerová}", title="Redox-dependent cytotoxicity of ferrocene derivatives and ROS-activated prodrugs based on ferrocenyliminoboronates", journal="JOURNAL OF INORGANIC BIOCHEMISTRY", year="2021", volume="224", number="1", pages="1--11", doi="10.1016/j.jinorgbio.2021.111561", issn="0162-0134", url="https://www.sciencedirect.com/science/article/pii/S0162013421002087?via%3Dihub" }