Detail publikace

In Situ Investigation of the Cytotoxic and Interfacial Characteristics of Titanium When Galvanically Coupled with Magnesium Using Scanning Electrochemical Microscopy

ASSERGHINE, A. ASHRAFI, A. MUKHERJEE, A. PETRLÁK, F. HEGER, Z. ŠVEC, P. RICHTERA, L. NAGY, L. SOUTO, R. NAGY, G. ADAM, V.

Originální název

In Situ Investigation of the Cytotoxic and Interfacial Characteristics of Titanium When Galvanically Coupled with Magnesium Using Scanning Electrochemical Microscopy

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Recently, the cytotoxic properties of galvanically coupled Ti-Mg particles have been shown in different cells. This cytotoxic effect has been attributed mainly to Mg due to its tendency to undergo activation when coupled with Ti, forming a galvanic cell consisting of an anode (Mg) and a cathode (Ti). However, the role of the Ti cathode has been ignored in explaining the cytotoxic effect of Ti-Mg particles due to its high resistance to corrosion. In this work, the role of titanium (Ti) in the cytotoxic mechanism of galvanically coupled Ti-Mg particles was examined. A model galvanic cell (MGC) was prepared to simulate the Mg-Ti particles. The electrochemical reactivity of the Ti sample and the pH change in it due to galvanic coupling with Mg were investigated using scanning electrochemical microscopy (SECM). It was observed that the Ti surface changed from passive to electrochemically active when coupled with Mg. Furthermore, after only 15 min of galvanic coupling with Mg, the pH in the electrolyte volume adjacent to the Ti surface increased to an alkaline pH value. The effects of the galvanic coupling of Ti and Mg, as well as those of the alkaline pH environment, on the viability of Hs27 fibroblast cells were investigated. It was shown that the viability of Hs27 cells significantly diminished when Mg and Ti were galvanically coupled compared to when the two metals were electrically disconnected. Thus, although Ti usually exhibited high corrosion resistance when exposed to physiological environments, an electrochemically active surface was observed when galvanically coupled with Mg, and this surface may participate in electron transfer reactions with chemical species in the neighboring environment; this participation resulted in the increased pH values above its surface and enhanced generation of reactive oxygen species. These features contributed to the development of cytotoxic effects by galvanically coupled Ti-Mg particles.

Klíčová slova

titanium; magnesium; galvanic coupling; local electrochemical activity; cytotoxic effects; pH variations; reactive oxygen species

Autoři

ASSERGHINE, A.; ASHRAFI, A.; MUKHERJEE, A.; PETRLÁK, F.; HEGER, Z.; ŠVEC, P.; RICHTERA, L.; NAGY, L.; SOUTO, R.; NAGY, G.; ADAM, V.

Vydáno

15. 9. 2021

ISSN

1944-8244

Periodikum

ACS APPL MATER INTER

Ročník

13

Číslo

36

Stát

Spojené státy americké

Strany od

43587

Strany do

43596

Strany počet

10

URL

https://pubs.acs.org/doi/abs/10.1021/acsami.1c10584

BibTex

@article{BUT172671,
  author="ASSERGHINE, A. and ASHRAFI, A. and MUKHERJEE, A. and PETRLÁK, F. and HEGER, Z. and ŠVEC, P. and RICHTERA, L. and NAGY, L. and SOUTO, R. and NAGY, G. and ADAM, V.",
  title="In Situ Investigation of the Cytotoxic and Interfacial Characteristics of Titanium When Galvanically Coupled with Magnesium Using Scanning Electrochemical Microscopy",
  journal="ACS APPL MATER INTER",
  year="2021",
  volume="13",
  number="36",
  pages="43587--43596",
  doi="10.1021/acsami.1c10584",
  issn="1944-8244",
  url="https://pubs.acs.org/doi/abs/10.1021/acsami.1c10584"
}