Detail publikačního výsledku

Compact High-Voltage AC Generator with Pulse Transformer for High-Frequency Irreversible Electroporation (H-FIRE)

FOLPRECHT, M.; ČERVINKA, D.; PROCHÁZKA, P.

Originální název

Compact High-Voltage AC Generator with Pulse Transformer for High-Frequency Irreversible Electroporation (H-FIRE)

Anglický název

Compact High-Voltage AC Generator with Pulse Transformer for High-Frequency Irreversible Electroporation (H-FIRE)

Druh

Článek WoS

Originální abstrakt

This paper is focused on a design of a high-voltage (HV) generator, which is proposed for a high-frequency irreversible electroporation (H-FIRE). The generator produces bursts of bipolar symmetrical pulses. Most HV sources used for cell electroporation are based on a controlled discharge of a capacitor into a resistive load. This solution is very simple, but it is associated with a certain risk of an uncontrolled discharge of the capacitor. We present a different type of the generator, where a DC-AC inverter with pulse transformer is used and where the mentioned risk is eliminated. Our generator is able to deliver bursts with variable length from 50 to 150 μs and a gap between bursts can be set from 0.5 to 1.5 s. Pulse frequency can be varied from 65 to 470 kHz and the output voltage is controlled in two ranges from 0 to 1.3 kV or from 0 to 2.5 kV. Results are presented with resistive load and with tissue impedance load.

Anglický abstrakt

This paper is focused on a design of a high-voltage (HV) generator, which is proposed for a high-frequency irreversible electroporation (H-FIRE). The generator produces bursts of bipolar symmetrical pulses. Most HV sources used for cell electroporation are based on a controlled discharge of a capacitor into a resistive load. This solution is very simple, but it is associated with a certain risk of an uncontrolled discharge of the capacitor. We present a different type of the generator, where a DC-AC inverter with pulse transformer is used and where the mentioned risk is eliminated. Our generator is able to deliver bursts with variable length from 50 to 150 μs and a gap between bursts can be set from 0.5 to 1.5 s. Pulse frequency can be varied from 65 to 470 kHz and the output voltage is controlled in two ranges from 0 to 1.3 kV or from 0 to 2.5 kV. Results are presented with resistive load and with tissue impedance load.

Klíčová slova

Cell electroporation; tissue ablation; capacitor bank; DC-AC inverter; DC-DC converter; frequency generator; high voltage; rectangular pulses; pulse transformer.

Klíčová slova v angličtině

Cell electroporation; tissue ablation; capacitor bank; DC-AC inverter; DC-DC converter; frequency generator; high voltage; rectangular pulses; pulse transformer.

Autoři

FOLPRECHT, M.; ČERVINKA, D.; PROCHÁZKA, P.

Rok RIV

2022

Vydáno

23.11.2021

Nakladatel

MDPI

ISSN

2079-9292

Periodikum

Electronics (MDPI)

Svazek

10

Číslo

23

Stát

Švýcarská konfederace

Strany od

1

Strany do

17

Strany počet

17

URL

https://www.mdpi.com/2079-9292/10/23/2898

Plný text v Digitální knihovně

http://hdl.handle.net/11012/203238

BibTex

@article{BUT174971,
  author="Martin {Folprecht} and Dalibor {Červinka} and Petr {Procházka}",
  title="Compact High-Voltage AC Generator with Pulse Transformer for High-Frequency Irreversible Electroporation (H-FIRE)",
  journal="Electronics (MDPI)",
  year="2021",
  volume="10",
  number="23",
  pages="1--17",
  doi="10.3390/electronics10232898",
  issn="2079-9292",
  url="https://www.mdpi.com/2079-9292/10/23/2898"
}

Dokumenty

electronics-10-02898-v2