Detail publikačního výsledku

Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy

GREGG, N.; SLADKÝ, V.; NEJEDLÝ, P.; MÍVALT, F.; KIM, I.; BALZEKAS, I.; STURGES, B.; CROWE, C.; PATTERSON, E.; VAN GOMPEL, J.; LUNDSTROM, B.; LEYDE, K.; DENISON, T.; BRINKMANN, B.; KŘEMEN, V.; WORRELL, G.

Originální název

Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy

Anglický název

Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy

Druh

Článek WoS

Originální abstrakt

Chronic brain recordings suggest that seizure risk is not uniform, but rather varies systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human and seven dogs with naturally occurring epilepsy had continuous intracranial EEG (median 298 days) using novel implantable sensing and stimulation devices. Two pet dogs and the human subject received concurrent thalamic deep brain stimulation (DBS) over multiple months. All subjects had circadian and multiday cycles in the rate of interictal epileptiform spikes (IES). There was seizure phase locking to circadian and multiday IES cycles in five and seven out of eight subjects, respectively. Thalamic DBS modified circadian (all 3 subjects) and multiday (analysis limited to the human participant) IES cycles. DBS modified seizure clustering and circadian phase locking in the human subject. Multiscale cycles in brain excitability and seizure risk are features of human and canine epilepsy and are modifiable by thalamic DBS.

Anglický abstrakt

Chronic brain recordings suggest that seizure risk is not uniform, but rather varies systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human and seven dogs with naturally occurring epilepsy had continuous intracranial EEG (median 298 days) using novel implantable sensing and stimulation devices. Two pet dogs and the human subject received concurrent thalamic deep brain stimulation (DBS) over multiple months. All subjects had circadian and multiday cycles in the rate of interictal epileptiform spikes (IES). There was seizure phase locking to circadian and multiday IES cycles in five and seven out of eight subjects, respectively. Thalamic DBS modified circadian (all 3 subjects) and multiday (analysis limited to the human participant) IES cycles. DBS modified seizure clustering and circadian phase locking in the human subject. Multiscale cycles in brain excitability and seizure risk are features of human and canine epilepsy and are modifiable by thalamic DBS.

Klíčová slova

epilepsy; DBS; long term trends; neuromodulation

Klíčová slova v angličtině

epilepsy; DBS; long term trends; neuromodulation

Autoři

GREGG, N.; SLADKÝ, V.; NEJEDLÝ, P.; MÍVALT, F.; KIM, I.; BALZEKAS, I.; STURGES, B.; CROWE, C.; PATTERSON, E.; VAN GOMPEL, J.; LUNDSTROM, B.; LEYDE, K.; DENISON, T.; BRINKMANN, B.; KŘEMEN, V.; WORRELL, G.

Rok RIV

2022

Vydáno

20.12.2021

Nakladatel

Springer Nature

Místo

BERLIN

ISSN

2045-2322

Periodikum

Scientific Reports

Svazek

11

Číslo

1

Stát

Spojené království Velké Británie a Severního Irska

Strany od

1

Strany do

12

Strany počet

12

URL

https://www.nature.com/articles/s41598-021-03555-7

Plný text v Digitální knihovně

http://hdl.handle.net/11012/203997

BibTex

@article{BUT176543,
  author="Nicholas M. {Gregg} and Vladimír {Sladký} and Petr {Nejedlý} and Filip {Mívalt} and Inyong {Kim} and Irena {Balzekas} and Beverly K {Sturges} and Chelsea M {Crowe} and Edward E. {Patterson} and Jamie J. {Van Gompel} and Brian {Lundstrom} and Kent {Leyde} and Timothy {Denison} and Benjamin H. {Brinkmann} and Václav {Křemen} and Gregory {Worrell}",
  title="Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy",
  journal="Scientific Reports",
  year="2021",
  volume="11",
  number="1",
  pages="1--12",
  doi="10.1038/s41598-021-03555-7",
  issn="2045-2322",
  url="https://www.nature.com/articles/s41598-021-03555-7"
}

Dokumenty

s41598-021-03555-7