Detail publikace

Achievable accuracy of resonating nanomechanical systems for mass sensing of larger analytes in GDa range

STACHIV, I. MACHŮ, Z. ŠEVEČEK, O. JENG, Y. LI, W. KOTOUL, M. PRÁŠEK, J.

Originální název

Achievable accuracy of resonating nanomechanical systems for mass sensing of larger analytes in GDa range

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Measurement of larger analytes such as many chemical and biological structures or viruses in gigadalton (GDa) range is a reminding fundamental task in analytical chemistry and life sciences, which can be possibly resolved with the resonating nanomechanical systems. Common approaches to mass sensing with these systems model the bound analyte as a point particle and assume the analyte does not change the vibrational mode shapes. However, for larger analytes their stiffness and size not only affect the resonant frequencies but also cause the significant changes in the vibrational mode shapes making their measurement highly challenging and still under-explored problem. Here, we develop a 3D model capable to accurately predict the resonant frequencies and vibrational mode shapes of the resonating nanomechanical systems with the bound analyte of arbitrary properties and size. Then, we examine in details the impact of analyte properties, size and its position of attachment on the resonant frequencies and vibrational mode shapes and, correspondingly, resolve a dispute over the achievable detection limits of the nanomechanical systems, especially for mass sensing of larger analytes. Furthermore, we identify three different sensing regimes, that is, the ultra-light, light and heavy, for which the effects of the analyte mass, stiffness, its size and the position of attachment on the accuracy of the determined mass can be separated. For the ultra-light regime (mass ratio < 10-3) the analyte stiffness and its size affect notably the resonant frequencies, the point mass approximation is inaccurate and the analyte can be identified by its mass and stiffness. For the light regime the point mass approximation is accurate, while for the heavy one (mass ratio > 2 center dot 10- 2) the mass effect dominates the frequency response and alters the vibrational mode shapes which, for the common approaches, yields the errors in the determined analyte mass. Finally, we also propose an easily accessible approach for the identification of larger analytes (in GDa range) that does not require the advanced computational tools or experimental setup, applicable to the majority of the clamped-clamped ends resonating nanomechanical systems.

Klíčová slova

Nanomechanical resonator; Mass sensing; Heavy mass spectrometry; FEM; Resonant frequency

Autoři

STACHIV, I.; MACHŮ, Z.; ŠEVEČEK, O.; JENG, Y.; LI, W.; KOTOUL, M.; PRÁŠEK, J.

Vydáno

15. 6. 2022

Nakladatel

PERGAMON-ELSEVIER SCIENCE LTD

Místo

OXFORD

ISSN

0020-7403

Periodikum

INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES

Ročník

224

Číslo

červen

Stát

Spojené království Velké Británie a Severního Irska

Strany od

1

Strany do

15

Strany počet

15

URL

https://www.sciencedirect.com/science/article/pii/S0020740322002636?pes=vor

BibTex

@article{BUT179484,
  author="STACHIV, I. and MACHŮ, Z. and ŠEVEČEK, O. and JENG, Y. and LI, W. and KOTOUL, M. and PRÁŠEK, J.",
  title="Achievable accuracy of resonating nanomechanical systems for mass sensing of larger analytes in GDa range",
  journal="INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES",
  year="2022",
  volume="224",
  number="červen",
  pages="1--15",
  doi="10.1016/j.ijmecsci.2022.107353",
  issn="0020-7403",
  url="https://www.sciencedirect.com/science/article/pii/S0020740322002636?pes=vor"
}