Detail publikace

Release of the Model Substance Through the Polymer Membrane into the Biological Environment

ZHURAULIOVA, D. PEKAŘ, M.

Originální název

Release of the Model Substance Through the Polymer Membrane into the Biological Environment

Typ

článek ve sborníku mimo WoS a Scopus

Jazyk

angličtina

Originální abstrakt

Modeling the transport or release of a substance from a gel system into a biological environment using COMSOL Multiphysics software plays an important role in understanding the processes required for proper design and optimization of an appropriate model. This model should accurately simulate transport and release of the substances from the gel three-dimensional structure in a certain biological environment (organism, soil). In this work, a two-dimensional axisymmetric model with defined materials is developed and evaluated, for which different values of porosity and diffusion coefficient are included. The diffusion coefficient is the most interesting variable in the field of transport properties, as it is influenced by the size of the molecules and the characteristics of the polymer network. By changing this variable, the course of release of the model substance can be influenced, which makes it possible to change the properties of the designed hydrogel systems according to the required applications. Transport of Diluted Species physics, in which the Porous Medium condition is included, and Laminar Flow physics are also present in the model, although the flow rate is zero, the gravity condition is introduced. The obtained graphs of the dependence of concentration on time and the model describe the course of transport and release of the substance through the polymer membrane into the biological environment. The designed model should correspond to a real sample of fertilizer or gel sphere containing a medicinal or bioactive substance (in this case filled with a model dye) to determine the release properties using appropriate experimental methods.

Klíčová slova

Release, polymer membrane, transport phenomena, COMSOL Multiphysics.

Autoři

ZHURAULIOVA, D.; PEKAŘ, M.

Vydáno

25. 10. 2023

Nakladatel

COMSOL Conference 2023 Munich

Místo

Mnichov, Německo

ISBN

978-1-7364524-1-7

Kniha

Papers and Presentation from the COMSOL Conference 2023

Strany počet

5

URL

https://www.comsol.com/papers-presentations/2023-munich

BibTex

@inproceedings{BUT185030,
  author="Darya {Zhurauliova} and Miloslav {Pekař}",
  title="Release of the Model Substance Through the Polymer Membrane into the Biological Environment",
  booktitle="Papers and Presentation from the COMSOL Conference 2023",
  year="2023",
  pages="5",
  publisher="COMSOL Conference 2023 Munich",
  address="Mnichov, Německo",
  isbn="978-1-7364524-1-7",
  url="https://www.comsol.com/papers-presentations/2023-munich"
}