Detail publikace

Tracing dsDNA Virus-Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences

BOHÁLOVÁ, N. CANTARA, A. BARTAS, M. KAURA, P. ŠŤASTNÝ, J. PEČINKA, P. FOJTA, M. BRÁZDA, V.

Originální název

Tracing dsDNA Virus-Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences

Typ

kapitola v knize

Jazyk

angličtina

Originální abstrakt

The importance of gene expression regulation in viruses based upon G-quadruplex may point to its potential utilization in therapeutic targeting. Here, we present analyses as to the occurrence of putative G-quadruplex-forming sequences (PQS) in all reference viral dsDNA genomes and evaluate their dependence on PQS occurrence in host organisms using the G4Hunter tool. PQS frequencies differ across host taxa without regard to GC content. The overlay of PQS with annotated regions reveals the localization of PQS in specific regions. While abundance in some, such as repeat regions, is shared by all groups, others are unique. There is abundance within introns of Eukaryota-infecting viruses, but depletion of PQS in introns of bacteria-infecting viruses. We reveal a significant positive correlation between PQS frequencies in dsDNA viruses and corresponding hosts from archaea, bacteria, and eukaryotes. A strong relationship between PQS in a virus and its host indicates their close coevolution and evolutionarily reciprocal mimicking of genome organization.

Klíčová slova

bioinformatics, G-quadruplex, G4Hunter

Autoři

BOHÁLOVÁ, N.; CANTARA, A.; BARTAS, M.; KAURA, P.; ŠŤASTNÝ, J.; PEČINKA, P.; FOJTA, M.; BRÁZDA, V.

Vydáno

1. 8. 2023

ISBN

978-3-0365-7444-8

Kniha

Impacts of Molecular Structure on Nucleic Acid-Protein Interactions

Strany od

39

Strany do

50

Strany počet

12

URL

https://mdpi-res.com/bookfiles/book/7184/Impacts_of_Molecular_Structure_on_Nucleic_AcidProtein_Interactions.pdf?v1683119827

BibTex

@inbook{BUT187818,
  author="Natália {Bohálová} and Alessio {Cantara} and Martin {Bartas} and Patrik {Kaura} and Jiří {Šťastný} and Petr {Pečinka} and Miroslav {Fojta} and Václav {Brázda}",
  title="Tracing dsDNA Virus-Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences",
  booktitle="Impacts of Molecular Structure on Nucleic Acid-Protein Interactions",
  year="2023",
  pages="39--50",
  isbn="978-3-0365-7444-8",
  url="https://mdpi-res.com/bookfiles/book/7184/Impacts_of_Molecular_Structure_on_Nucleic_AcidProtein_Interactions.pdf?v1683119827"
}