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MOHAMAD, N. EZATI, M. HASHEMI, A. POLÁŠKOVÁ, K. ZUMBERG, I. ČMIEL, V. SCHÄFER, J. ZAJÍČKOVÁ, L.
Originální název
Enhancing Wound Healing with Bioprinted Chitosan Hydrogels Treated by Cold Atmospheric Plasma Jets
Typ
abstrakt
Jazyk
angličtina
Originální abstrakt
Uncontrolled bleeding in many kinds of injuries and accidents is a major factor leading to death. Severe blood loss can result in hypothermia, coagulopathy, and multiorgan failure, while bacterial infections can further complicate the recovery process. Addressing this, we investigate the application of plasma treatment to improve the antibacterial characteristics of chitosan (CS) hydrogels and augment their suitability for bioprinting applications. We employ 3D bioprinting to fabricate CS hydrogel scaffolds because it has the capacity to closely mimic the architecture of human tissues. The 3D printing precision allows fabrication of specific supports and improved transfer of essential nutrients, which is crucial in cases of severe bleeding where conventional hydrogels and dressings may not be adequate. Plasma activation enhances hydrogels by introducing oxygen functionalities, including reactive oxygen and nitrogen species (RONS), providing a novel approach to wound healing. We investigated two approaches that use cold atmospheric pressure plasma jets: plasma treatment of uncrosslinked CS solutions (A) and surface modification of printed CS hydrogel scaffolds (B). Our initial findings suggested that the plasma-treated hydrogel scaffolds exhibit higher hydrophilicity, i. e. reduction of water contact angle. Cell viability experiments showed that plasma-treated hydrogels significantly enhanced fibroblast cell morphology and growth. Our findings indicate that plasma-treated CS hydrogels may find applications in wound dressings.
Klíčová slova
Plasma, RONS, Chitosan, Hydrogel, Bioprinting, Wound healing
Autoři
MOHAMAD, N.; EZATI, M.; HASHEMI, A.; POLÁŠKOVÁ, K.; ZUMBERG, I.; ČMIEL, V.; SCHÄFER, J.; ZAJÍČKOVÁ, L.
Vydáno
13. 9. 2024
Nakladatel
Ljubljana, Jožef Stefan Institute
Místo
Ljubljana, Slovenia
ISBN
978-961-264-293-8
Kniha
Book of abstracts – 10th International Conference on Plasma Medicine and 9th International Workshop on Plasma for Cancer Treatment
Strany od
207
Strany do
Strany počet
1
URL
https://f6-ge.ijs.si/icpm10/?page_id=1269
BibTex
@misc{BUT188672, author="Noor {Mohamad} and Masoumeh {Ezati} and Amir {Hashemi} and Kateřina {Polášková} and Inna {Zumberg} and Vratislav {Čmiel} and Jan {Schäfer} and Lenka {Zajíčková}", title="Enhancing Wound Healing with Bioprinted Chitosan Hydrogels Treated by Cold Atmospheric Plasma Jets", booktitle="Book of abstracts – 10th International Conference on Plasma Medicine and 9th International Workshop on Plasma for Cancer Treatment", year="2024", pages="207--207", publisher="Ljubljana, Jožef Stefan Institute", address="Ljubljana, Slovenia", isbn="978-961-264-293-8", url="https://f6-ge.ijs.si/icpm10/?page_id=1269", note="abstract" }