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Lipovy, B. Vacek, L. Kleknerova, DP. Jeklova, E. Liskova, L. Holoubek, J. Matyskova, D. Ruzicka, F
Originální název
Porcine model of a complicated skin and soft tissue infection caused by Pseudomonas aeruginosa
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
Pseudomonas aeruginosa poses a significant threat to both immunocompetent and immunocompromised individuals, often resulting in life -threatening infections. With increasing antimicrobial resistance, novel therapeutic strategies are urgently needed. Although animal models are crucial for preclinical studies, limited data are available for porcine models, more specifically for P. aeruginosa complicated skin and soft tissue infections (cSSTIs). This study presents a novel porcine model inducing and sustaining cSSTI for 14 days. Six pigs (120 wounds) were used for the development of infections, and within this group, two pigs (40 wounds) were used to evaluate the progression of the cSSTI infection. The model demonstrated bacterial loads of more than 10 7 CFU/ gram of tissue or higher. The cSSTI fully developed within three days and remained well above these levels until day 14 post -infection. Due to the immunocompetence of this model, all the immunological processes associated with the response to the presence of infection and the wound healing process are preserved.
Klíčová slova
ESKAPE pathogen; model development; pig; wound
Autoři
Lipovy, B.; Vacek, L.; Kleknerova, DP.; Jeklova, E.; Liskova, L.; Holoubek, J.; Matyskova, D.; Ruzicka, F
Vydáno
10. 9. 2024
Nakladatel
CZECH ACADEMY AGRICULTURAL SCIENCES
Místo
PRAGUE
ISSN
1805-9392
Periodikum
VETERINARNI MEDICINA
Ročník
69
Číslo
6
Stát
Česká republika
Strany od
191
Strany do
197
Strany počet
7
URL
https://vetmed.agriculturejournals.cz/artkey/vet-202406-0004_porcine-model-of-a-complicated-skin-and-soft-tissue-infection-caused-by-pseudomonas-aeruginosa.php
BibTex
@article{BUT189940, author="Břetislav {Lipový} and Lukáš {Vacek} and Dominika {Polaštík Kleknerová} and Edita {Jeklová} and Lenka {Lišková} and Jakub {Holoubek} and Dominika {Matýsková} and Filip {Růžička}", title="Porcine model of a complicated skin and soft tissue infection caused by Pseudomonas aeruginosa", journal="VETERINARNI MEDICINA", year="2024", volume="69", number="6", pages="191--197", doi="10.17221/25/2024-VETMED", issn="1805-9392", url="https://vetmed.agriculturejournals.cz/artkey/vet-202406-0004_porcine-model-of-a-complicated-skin-and-soft-tissue-infection-caused-by-pseudomonas-aeruginosa.php" }