Detail publikace

In Vivo Assessment on Freeze-Cast Calcium Phosphate-Based Scaffolds with a Selective Cell/Tissue Ingrowth

Pejchalová, L. Pejchal, J. Roleček, J. Vojníkova, M. Chlup, Z. Mařák, V. González-Sánchez, M. Čížková, J. Salamon, D.

Originální název

In Vivo Assessment on Freeze-Cast Calcium Phosphate-Based Scaffolds with a Selective Cell/Tissue Ingrowth

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Highly porous bioceramic scaffolds are widely used as bone substitutes in many applications. However, the use of bioceramics is often limited to hard tissues due to the risk of potential soft tissue calcification. A further limitation of highly porous bioceramic scaffolds is their poor mechanical stability, manifested by their tendency to break under stress. In our study, highly porous CaP-based scaffolds were prepared via freeze-casting with longitudinal and oriented pores ranging from 10 to 20 mu m and a relative porosity of similar to 70%. The resulting scaffolds achieved a flexural strength of 10.6 +/- 2.7 MPa, which, in conjunction with their favorable bioactivity, made them suitable for in vivo testing. The prepared scaffolds were subcutaneously implanted in rats for two distinct periods: 6 weeks and 6 months, respectively. The subsequent development of fibrous tissue and involvement of myofibroblasts, newly formed vessels, and macrophages were observed, with notable changes in spatial and temporal distributions within the implantation. The absence of calcification in the surrounding soft tissue, as a result of the narrow pore geometry, indicates the opportunity to tailor the scaffold behavior for soft tissue regeneration.

Klíčová slova

in vivo; tissue engineering; scaffolds; calcium phosphates; freeze-casting; bioceramics

Autoři

Pejchalová, L.; Pejchal, J.; Roleček, J.; Vojníkova, M.; Chlup, Z.; Mařák, V.; González-Sánchez, M.; Čížková, J.; Salamon, D.

Vydáno

21. 10. 2024

Nakladatel

AMER CHEMICAL SOC

Místo

WASHINGTON

ISSN

1944-8244

Periodikum

ACS APPL MATER INTER

Ročník

16

Číslo

43

Stát

Spojené státy americké

Strany od

58326

Strany do

58336

Strany počet

11

URL

https://pubs.acs.org/doi/10.1021/acsami.4c12715

Plný text v Digitální knihovně

http://hdl.handle.net/11012/250794

BibTex

@article{BUT191213,
  author="Lucie {Mařáková} and Jaroslav {Pejchal} and Jakub {Roleček} and Michaela {Vojníková} and Zdeněk {Chlup} and Vojtěch {Mařák} and Manuela {González-Sánchez} and Jana {Čížková} and David {Salamon}",
  title="In Vivo Assessment on Freeze-Cast Calcium Phosphate-Based Scaffolds with a Selective Cell/Tissue Ingrowth",
  journal="ACS APPL MATER INTER",
  year="2024",
  volume="16",
  number="43",
  pages="58326--58336",
  doi="10.1021/acsami.4c12715",
  issn="1944-8244",
  url="https://pubs.acs.org/doi/10.1021/acsami.4c12715"
}