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GALANDÁKOVÁ, A. ULRICHOVÁ, J. LANGOVÁ, K. HANÁKOVÁ, A. VRBKA, M. HARTL, M. GALLO, J.
Originální název
Characteristics of synovial fluid required for optimization of lubrication fluid for biotribological experiments
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
Wear testing of total joint replacement (TJR) is mandatory in preclinical testing before implantation of TJR into the human body. Testing is governed by current international standards that recommend bovine serum (BS) as a lubricating fluid to replace synovial fluid (SF). Recently, the use of BS has been criticized because of differences in content, fluid characteristics, and nonhuman origin. As a result, a more realistic lubricant mimicking SF is needed. To define SF composition, we analyzed SF obtained during revisions of total hip and knee arthroplasties and compared it with SF obtained during primary arthroplasties and from patients without TJR. Samples were acquired from 152 patients. We found that the median total protein concentration for all SF was 36.8 mg/mL, which is significantly higher than concentrations currently recommended by the ISO standards. The gama globulin concentration was significantly higher and the phospholipid concentration significantly lower in patients with revision of TJR compared with patients without TJR. No significant difference was found in hyaluronic acid concentration and viscosity among the groups. Our results support the need to improve the definition of a more clinically relevant wear testing lubricant in the ISO standards.
Klíčová slova
total hip and knee replacement, protein, hyaluronic acid, phospholipid, viscosity
Autoři
GALANDÁKOVÁ, A.; ULRICHOVÁ, J.; LANGOVÁ, K.; HANÁKOVÁ, A.; VRBKA, M.; HARTL, M.; GALLO, J.
Vydáno
18. 4. 2016
Nakladatel
John Wiley & Sons Inc.
Místo
USA
ISSN
1552-4981
Periodikum
Journal of biomedical materials research. Part B, Applied biomaterials (Electronic)
Ročník
105
Číslo
6
Stát
Spojené státy americké
Strany od
1422
Strany do
1431
Strany počet
10
URL
http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33663/full
BibTex
@article{BUT126663, author="GALANDÁKOVÁ, A. and ULRICHOVÁ, J. and LANGOVÁ, K. and HANÁKOVÁ, A. and VRBKA, M. and HARTL, M. and GALLO, J.", title="Characteristics of synovial fluid required for optimization of lubrication fluid for biotribological experiments", journal="Journal of biomedical materials research. Part B, Applied biomaterials (Electronic)", year="2016", volume="105", number="6", pages="1422--1431", doi="10.1002/jbm.b.33663", issn="1552-4981", url="http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33663/full" }