Detail publikace

Silicane Derivative Increases Doxorubicin Efficacy in an Ovarian Carcinoma Mouse Model: Fighting Drug Resistance

FOJTŮ, M. BALVAN, J. VIČAR, T. POLANSKÁ, H. PELTANOVÁ, B. MATĚJKOVÁ, S. RAUDENSKÁ, M. ŠTURALA, J. MAYORGA BURREZO, P. MASAŘÍK, M. PUMERA, M.

Originální název

Silicane Derivative Increases Doxorubicin Efficacy in an Ovarian Carcinoma Mouse Model: Fighting Drug Resistance

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

The development of cancer resistance continues to represent a bottleneck of cancer therapy. It is one of the leading factors preventing drugs to exhibit their full therapeutic potential. Consequently, it reduces the efficacy of anticancer therapy and causes the survival rate of therapy-resistant patients to be far from satisfactory. Here, an emerging strategy for overcoming drug resistance is proposed employing a novel two-dimensional (2D) nanomaterial polysiloxane (PSX). We have reported on the synthesis of PSX nanosheets (PSX NSs) and proved that they have favorable properties for biomedical applications. PSX NSs evinced unprecedented cytocompatibility up to the concentration of 300 mu g/mL, while inducing very low level of red blood cell hemolysis and were found to be highly effective for anticancer drug binding. PSX NSs enhanced the efficacy of the anticancer drug doxorubicin (DOX) by around 27.8-43.4% on average and, interestingly, were found to be especially effective in the therapy of drug-resistant tumors, improving the effectiveness of up to 52%. Fluorescence microscopy revealed improved retention of DOX within the drug-resistant cells when bound on PSX NSs. DOX bound on the surface of PSX NSs, i.e., PSX@DOX, improved, in general, the DOX cytotoxicity in vitro. More importantly, PSX@DOX reduced the growth of DOX-resistant tumors in vivo with 3.5 times better average efficiency than the free drug. Altogether, this paper represents an introduction of a new 2D nanomaterial derived from silicane and pioneers its biomedical application. As advances in the field of material synthesis are rapidly progressing, novel 2D nanomaterials with improved properties are being synthesized and await thorough exploration. Our findings further provide a better understanding of the mechanisms involved in the cancer resistance and can promote the development of a precise cancer therapy.

Klíčová slova

2D nanomaterials; silicene; polysiloxane; nanosheets; targeted drug delivery; doxorubicin; ovarian cancer; drug resistance

Autoři

FOJTŮ, M.; BALVAN, J.; VIČAR, T.; POLANSKÁ, H.; PELTANOVÁ, B.; MATĚJKOVÁ, S.; RAUDENSKÁ, M.; ŠTURALA, J.; MAYORGA BURREZO, P.; MASAŘÍK, M.; PUMERA, M.

Vydáno

14. 7. 2021

Nakladatel

AMER CHEMICAL SOC

Místo

WASHINGTON

ISSN

1944-8252

Periodikum

ACS applied materials & interfaces

Ročník

13

Číslo

27

Stát

Spojené státy americké

Strany od

31355

Strany do

31370

Strany počet

16

URL

https://pubs.acs.org/doi/10.1021/acsami.0c20458

BibTex

@article{BUT172538,
  author="Michaela {Fojtů} and Jan {Balvan} and Tomáš {Vičar} and Hana {Polanská} and Barbora {Peltanová} and Stanislava {Matějková} and Martina {Raudenská} and Jiří {Šturala} and Paula {Mayorga Burrezo} and Michal {Masařík} and Martin {Pumera}",
  title="Silicane Derivative Increases Doxorubicin Efficacy in an Ovarian Carcinoma Mouse Model: Fighting Drug Resistance",
  journal="ACS applied materials & interfaces",
  year="2021",
  volume="13",
  number="27",
  pages="31355--31370",
  doi="10.1021/acsami.0c20458",
  issn="1944-8252",
  url="https://pubs.acs.org/doi/10.1021/acsami.0c20458"
}