Detail publikace

Heart rate and age modulate retinal pulsatile patterns

LABOUNKOVÁ, I. LABOUNEK, R. KOLÁŘ, R. TORNOW, R. BABBS, C. MCCLELLAND, C. MILLER, B. NESTRAŠIL, I.

Originální název

Heart rate and age modulate retinal pulsatile patterns

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Video-recordings of retinal pulsatile patterns in human eye are modulated by heart rate and age. This invivo evidence fundamentally impacts modeling of retinal function and clinical design in wide range of medical specialties. Theoretical models of retinal hemodynamics showed the modulation of retinal pulsatile patterns (RPPs) by heart rate (HR), yet in-vivo validation and scientific merit of this biological process is lacking. Such evidence is critical for result interpretation, study design, and (patho-)physiological modeling of human biology spanning applications in various medical specialties. In retinal hemodynamic video-recordings, we characterize the morphology of RPPs and assess the impact of modulation by HR or other variables. Principal component analysis isolated two RPPs, i.e., spontaneous venous pulsation (SVP) and optic cup pulsation (OCP). Heart rate modulated SVP and OCP morphology (p(FDR) < 0.05); age modulated SVP morphology (p(FDR) < 0.05). In addition, age and HR demonstrated the effect on between-group differences. This knowledge greatly affects future study designs, analyses of between-group differences in RPPs, and biophysical models investigating relationships between RPPs, intracranial, intraocular pressures, and cardiovascular physiology.

Klíčová slova

blood flow; image processing; ocular hypertension; optical imaging; translational research

Autoři

LABOUNKOVÁ, I.; LABOUNEK, R.; KOLÁŘ, R.; TORNOW, R.; BABBS, C.; MCCLELLAND, C.; MILLER, B.; NESTRAŠIL, I.

Vydáno

14. 6. 2022

Nakladatel

NATURE PORTFOLIO

Místo

BERLIN

ISSN

2399-3642

Periodikum

Communications Biology

Ročník

5

Číslo

1

Stát

Spojené království Velké Británie a Severního Irska

Strany od

1

Strany do

10

Strany počet

10

URL

https://www.nature.com/articles/s42003-022-03441-6

Plný text v Digitální knihovně

http://hdl.handle.net/11012/208117

BibTex

@article{BUT178352,
  author="Ivana {Labounková} and René {Labounek} and Radim {Kolář} and Ralf-Peter {Tornow} and Charles F. {Babbs} and Collin {McClelland} and Benjamin R. {Miller} and Igor {Nestrašil}",
  title="Heart rate and age modulate retinal pulsatile patterns",
  journal="Communications Biology",
  year="2022",
  volume="5",
  number="1",
  pages="1--10",
  doi="10.1038/s42003-022-03441-6",
  issn="2399-3642",
  url="https://www.nature.com/articles/s42003-022-03441-6"
}