Detail publikace

Enzyme-Photocatalyst Tandem Microrobot Powered by Urea for Escherichia coli Biofilm Eradication

VILLA, K. SOPHA, H. ZELENKA, J. MOTOLA, M. DĚKANOVSKÝ, L. CHYLII BEKETOVA, D. MACÁK, J. RUML, T. PUMERA, M.

Originální název

Enzyme-Photocatalyst Tandem Microrobot Powered by Urea for Escherichia coli Biofilm Eradication

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Urinary-based infections affect millions of people worldwide. Such bacterial infections are mainly caused by Escherichia coli (E. coli) biofilm formation in the bladder and/or urinary catheters. Herein, the authors present a hybrid enzyme/photocatalytic microrobot, based on urease-immobilized TiO2/CdS nanotube bundles, that can swim in urea as a biocompatible fuel and respond to visible light. Upon illumination for 2 h, these microrobots are able to remove almost 90% of bacterial biofilm, due to the generation of reactive radicals, while bare TiO2/CdS photocatalysts (non-motile) or urease-coated microrobots in the dark do not show any toxic effect. These results indicate a synergistic effect between the self-propulsion provided by the enzyme and the photocatalytic activity induced under light stimuli. This work provides a photo-biocatalytic approach for the design of efficient light-driven microrobots with promising applications in microbiology and biomedicine.

Klíčová slova

bacterial biofilms; enzymatic; micromotors; photocatalysis; TiO; (2) nanotubes; urinary infections

Autoři

VILLA, K.; SOPHA, H.; ZELENKA, J.; MOTOLA, M.; DĚKANOVSKÝ, L.; CHYLII BEKETOVA, D.; MACÁK, J.; RUML, T.; PUMERA, M.

Vydáno

1. 9. 2022

Nakladatel

Wiley-VCH

Místo

WEINHEIM

ISSN

1613-6829

Periodikum

Small

Ročník

18

Číslo

36

Stát

Spolková republika Německo

Strany od

1

Strany do

8

Strany počet

8

URL

https://onlinelibrary.wiley.com/doi/10.1002/smll.202106612

BibTex

@article{BUT178709,
  author="Katherine {Villa} and Hanna Ingrid {Sopha} and Jaroslav {Zelenka} and Martin {Motola} and Lukáš {Děkanovský} and Darya {Chylii Beketova} and Jan {Macák} and Tomáš {Ruml} and Martin {Pumera}",
  title="Enzyme-Photocatalyst Tandem Microrobot Powered by Urea for Escherichia coli Biofilm Eradication",
  journal="Small",
  year="2022",
  volume="18",
  number="36",
  pages="1--8",
  doi="10.1002/smll.202106612",
  issn="1613-6829",
  url="https://onlinelibrary.wiley.com/doi/10.1002/smll.202106612"
}