Detail publikace

Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract

ORAL, Ç. USSIA, M. URSO, M. SALÁT, J. NOVOBILSKÝ, A. ŠTEFÁNIK, M. RŮŽEK, D. PUMERA, M.

Originální název

Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Magnetic nanorobots offer wireless navigation capability in hard-to-reach areas of the human body for targeted therapy and diagnosis. Though in vivo imaging is required for guidance of the magnetic nanorobots toward the target areas, most of the imaging techniques are inadequate to reveal the potential locomotion routes. This work proposes the use of radiopaque magnetic nanorobots along with microcomputed tomography (microCT) for localized in vivo imaging applications. The nanorobots consist of a contrast agent, barium sulfate (BaSO4), magnetized by the decoration of magnetite (Fe3O4) particles. The magnetic features lead to actuation under rotating magnetic fields and enable precise navigation in a microfluidic channel used to simulate confined spaces of the body. In this channel, the intrinsic radiopacity of the nanorobots also provides the possibility to reveal the internal structures by X-ray contrast. Furthermore, in vitro analysis indicates nontoxicity of the nanorobots. In vivo experiments demonstrate localization of the nanorobots in a specific part of the gastrointestinal (GI) tract upon the influence of the magnetic field, indicating the efficient control even in the presence of natural peristaltic movements. The nanorobots reported here highlight that smart nanorobotic contrast agents can improve the current imaging-based diagnosis techniques by providing untethered controllability in vivo.

Klíčová slova

computed tomography; gastrointestinal tract; magnetic actuation; medical imaging; nanomotors; nanoswimmers; tracking

Autoři

ORAL, Ç.; USSIA, M.; URSO, M.; SALÁT, J.; NOVOBILSKÝ, A.; ŠTEFÁNIK, M.; RŮŽEK, D.; PUMERA, M.

Vydáno

24. 3. 2023

Nakladatel

WILEY

Místo

HOBOKEN

ISSN

2192-2640

Periodikum

Advanced Healthcare Materials

Ročník

12

Číslo

8

Stát

Spojené království Velké Británie a Severního Irska

Strany počet

9

URL

https://onlinelibrary.wiley.com/doi/10.1002/adhm.202202682

BibTex

@article{BUT182385,
  author="Çaǧatay Mert {Oral} and Martina {Ussia} and Mario {Urso} and Jiří {Salát} and Adam {Novobilský} and Michal {Štefánik} and Daniel {Růžek} and Martin {Pumera}",
  title="Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract",
  journal="Advanced Healthcare Materials",
  year="2023",
  volume="12",
  number="8",
  pages="9",
  doi="10.1002/adhm.202202682",
  issn="2192-2640",
  url="https://onlinelibrary.wiley.com/doi/10.1002/adhm.202202682"
}