Detail publikace
The first solid-state route to luminescent Au(I)-glutathionate and its pH-controlled transformation into ultrasmall oligomeric Au10-12(SG)10-12 nanoclusters for application in cancer radiotheraphy
DEÁK, A. SZABÓ, P. BEDNAŘÍKOVÁ, V. CIHLÁŘ, J. DEMETER, A. REMEŠOVÁ, M. COLACINO, E. ČELKO, L.
Originální název
The first solid-state route to luminescent Au(I)-glutathionate and its pH-controlled transformation into ultrasmall oligomeric Au10-12(SG)10-12 nanoclusters for application in cancer radiotheraphy
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
There is still a need for synthetic approaches that are much faster, easier to scale up, more robust and efficient for generating gold(I)-thiolates that can be easily converted into gold-thiolate nanoclusters. Mechanochemical methods can offer significantly reduced reaction times, increased yields and straightforward recovery of the product, compared to the solution-based reactions. For the first time, a new simple, rapid and efficient mechanochemical redox method in a ball-mill was developed to produce the highly luminescent, pH-responsive Au(I)-glutathionate, [Au(SG)]( n ). The efficient productivity of the mechanochemical redox reaction afforded orange luminescent [Au(SG)]( n ) in isolable amounts (mg scale), usually not achieved by more conventional methods in solution. Then, ultrasmall oligomeric Au10-12(SG)(10-12) nanoclusters were prepared by pH-triggered dissociation of [Au(SG)]( n ). The pH-stimulated dissociation of the Au(I)-glutathionate complex provides a time-efficient synthesis of oligomeric Au10-12(SG)(10-12) nanoclusters, it avoids high-temperature heating or the addition of harmful reducing agent (e.g., carbon monoxide). Therefore, we present herein a new and eco-friendly methodology to access oligomeric glutathione-based gold nanoclusters, already finding applications in biomedical field as efficient radiosensitizers in cancer radiotherapy.
Klíčová slova
bioactive molecules; gold nanocluster; gold thiolate; glutathione; mechanochemistry
Autoři
DEÁK, A.; SZABÓ, P.; BEDNAŘÍKOVÁ, V.; CIHLÁŘ, J.; DEMETER, A.; REMEŠOVÁ, M.; COLACINO, E.; ČELKO, L.
Vydáno
5. 6. 2023
Nakladatel
Frontiers Media
Místo
LAUSANNE
ISSN
2296-2646
Periodikum
Frontiers in Chemistry
Ročník
11
Číslo
6
Stát
Švýcarská konfederace
Strany počet
11
URL
Plný text v Digitální knihovně
BibTex
@article{BUT185020,
author="Andréa {Deák} and Pál T. {Szabó} and Vendula {Bednaříková} and Jaroslav {Cihlář} and Attila {Demeter} and Michaela {Remešová} and Evelina {Colacino} and Ladislav {Čelko}",
title="The first solid-state route to luminescent Au(I)-glutathionate and its pH-controlled transformation into ultrasmall oligomeric Au10-12(SG)10-12 nanoclusters for application in cancer radiotheraphy",
journal="Frontiers in Chemistry",
year="2023",
volume="11",
number="6",
pages="11",
doi="10.3389/fchem.2023.1178225",
issn="2296-2646",
url="https://www.frontiersin.org/articles/10.3389/fchem.2023.1178225/full"
}