Detail publikace

Self-Assembled Hydrogel Membranes with Structurally Tunable Mechanical and Biological Properties

ABDEL-RAHMAN, R. ABDELLATIF, A. FRANKOVA, J. PIANA, F. KALINA, L. GAJDOŠOVÁ, V. KAPRALKOVA, L. THOTTAPPALIJ, M.A. ANČÁŘ, J.

Originální název

Self-Assembled Hydrogel Membranes with Structurally Tunable Mechanical and Biological Properties

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Using supramolecular self-assembled nanocomposite materials made from protein and polysaccharide components is becoming more popular because of their unique properties, such as biodegradability, hierarchical structures, and tunable multifunctionality. However, the fabrication of these materials in a reproducible way remains a challenge. This study presents a new evaporation-induced self-assembly method producing layered hydrogel membranes (LHMs) using tropocollagen grafted by partially deacetylated chitin nanocrystals (CO-g-ChNCs). ChNCs help stabilize tropocollagen's helical conformation and fibrillar structure by forming a hierarchical microstructure through chemical and physical interactions. The LHMs show improved mechanical properties, cytocompatibility, and the ability to control drug release using octenidine dihydrochloride (OCT) as a drug model. Because of the high synergetic performance between CO and ChNCs, the modulus, strength, and toughness increased significantly compared to native CO. The biocompatibility of LHM was tested using the normal human dermal fibroblast (NHDF) and the human osteosarcoma cell line (Saos-2). Cytocompatibility and cell adhesion improved with the introduction of ChNCs. The extracted ChNCs are used as a reinforcing nanofiller to enhance the performance properties of tropocollagen hydrogel membranes and provide new insights into the design of novel LHMs that could be used for various medical applications, such as control of drug release in the skin and bone tissue regeneration.

Klíčová slova

REDUCED GRAPHENE OXIDE; ARTIFICIAL NACRE; CROSS-LINKING; ANTIBACTERIAL ACTIVITY; COLLAGEN; NANOCOMPOSITES; ALGINATE; PIEZOELECTRICITY; ATTACHMENT; SCAFFOLDS

Autoři

ABDEL-RAHMAN, R.; ABDELLATIF, A.; FRANKOVA, J.; PIANA, F.; KALINA, L.; GAJDOŠOVÁ, V.; KAPRALKOVA, L.; THOTTAPPALIJ, M.A.; ANČÁŘ, J.

Vydáno

10. 6. 2024

Nakladatel

AMER CHEMICAL SOC

Místo

WASHINGTON

ISSN

1525-7797

Periodikum

BIOMACROMOLECULES

Ročník

25

Číslo

6

Stát

Spojené státy americké

Strany od

3449

Strany do

3463

Strany počet

15

URL

https://pubs.acs.org/doi/10.1021/acs.biomac.4c00082

BibTex

@article{BUT188813,
  author="ABDEL-RAHMAN, R. and ABDELLATIF, A. and FRANKOVA, J. and PIANA, F. and KALINA, L. and GAJDOŠOVÁ, V. and KAPRALKOVA, L. and THOTTAPPALIJ, M.A. and ANČÁŘ, J.",
  title="Self-Assembled Hydrogel Membranes with Structurally Tunable Mechanical and Biological Properties",
  journal="BIOMACROMOLECULES",
  year="2024",
  volume="25",
  number="6",
  pages="3449--3463",
  doi="10.1021/acs.biomac.4c00082",
  issn="1525-7797",
  url="https://pubs.acs.org/doi/10.1021/acs.biomac.4c00082"
}