Detail publikace

Multifunctional graphene quantum dots: A therapeutic strategy for neurodegenerative diseases by regulating calcium influx, crossing the blood-brain barrier and inhibiting Aβ-protein aggregation

GOMEZ PEREZ, I. KŘÍŽKOVÁ, P. DOLEČKOVÁ, A. CARDO, L. WETZL, C. PIZÚROVÁ, N. PRATO, M. MEDALOVÁ, J. ZAJÍČKOVÁ, L.

Originální název

Multifunctional graphene quantum dots: A therapeutic strategy for neurodegenerative diseases by regulating calcium influx, crossing the blood-brain barrier and inhibiting Aβ-protein aggregation

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Multifunctional nanoparticles could be the hallmark for the treatment of neurodegenerative diseases. Dissociation of protein aggregates causing neuronal damage and transfer of specific drugs which can downregulate neuronal excitotoxicity by inhibiting glutamatergic N-Methyl-D-Aspartate-receptors (NMDA) and then reducing calcium influx are among the main factors to consider for proper therapy. Here, we present a multiplatform based on nitrogen-doped graphene quantum dots (NGQDs) with such functionalities. The NGQDs were functionalized with Memantine, the clinically used drug, via covalent and non-covalent coupling, and we confirmed that the pharmaceutical activity was not altered. Apart from that, using xCELLigence technology and flow cytometric analysis of ABC transporter function, we uncovered that the ABC transporters of the blood-brain barrier (BBB) do not affect the ability of NGQD to cross BBB. Surprisingly, this study found that NGQDs have an inhibitory effect on NMDA receptors, thus supporting the action of Memantine. Moreover, NGQDs and their derivatives demonstrated the potential to dissociate beta-amyloid aggregates while possessing features suitable for bioimaging in various cell lines.

Klíčová slova

Carbon dots; Memantine; Protein aggregation; Blood-brain barrier; Bioimaging

Autoři

GOMEZ PEREZ, I.; KŘÍŽKOVÁ, P.; DOLEČKOVÁ, A.; CARDO, L.; WETZL, C.; PIZÚROVÁ, N.; PRATO, M.; MEDALOVÁ, J.; ZAJÍČKOVÁ, L.

Vydáno

1. 2. 2024

Nakladatel

ELSEVIER

Místo

AMSTERDAM

ISSN

2352-9407

Periodikum

Applied Materials Today

Ročník

36

Číslo

102072

Stát

Nizozemsko

Strany počet

9

URL

https://www.sciencedirect.com/science/article/pii/S2352940724000180?via%3Dihub

BibTex

@article{BUT188954,
  author="Inmaculada Jennifer {Gomez Perez} and Petra {Křížková} and Anna {Dolečková} and Lucia {Cardo} and Cecília {Wetzl} and Naděžda {Pizúrová} and Maurizio {Prato} and Jiřina {Medalová} and Lenka {Zajíčková}",
  title="Multifunctional graphene quantum dots: A therapeutic strategy for neurodegenerative diseases by regulating calcium influx, crossing the blood-brain barrier and inhibiting Aβ-protein aggregation",
  journal="Applied Materials Today",
  year="2024",
  volume="36",
  number="102072",
  pages="9",
  doi="10.1016/j.apmt.2024.102072",
  issn="2352-9407",
  url="https://www.sciencedirect.com/science/article/pii/S2352940724000180?via%3Dihub"
}