Detail publikace

OLEYL-HYALURONAN SELF-ASSEMBLY AND ITS INTERACTIONS WITH BOVINE SERUM ALBUMIN

SITA, J. ČEPA, M. VELEBNÝ, V. ONDREÁŠ, F.

Originální název

OLEYL-HYALURONAN SELF-ASSEMBLY AND ITS INTERACTIONS WITH BOVINE SERUM ALBUMIN

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

Oleyl-hyaluronan (O-HA) is an amphiphilic polysaccharide that can be used as a drug carrier. Its self-assembly was improved when using a solvent with ions due to charge compensation on the HA backbone. Moreover, the functional properties such as drug loading capacity and its penetration into the skin were enhanced. Interactions with serum proteins are often considered a bottleneck for carriers' application. Interactions of O-HA and bovine serum albumin (BSA) were elucidated by various techniques and divided into three regimes. Structural changes were found and described. Resulting system retained the drug effectively.

Klíčová slova

self-assembly; hyaluronan; hydrophobically modified; BSA;

Autoři

SITA, J.; ČEPA, M.; VELEBNÝ, V.; ONDREÁŠ, F.

Vydáno

1. 1. 2022

ISBN

978-80-88307-12-9

Kniha

PROCEEDINGS OF THE 18TH INTERNATIONAL CONFERENCE ON POLYSACCHARIDES-GLYCOSCIENCE

Strany od

110

Strany do

113

Strany počet

4

URL

https://www.webofscience.com/wos/woscc/full-record/WOS:001249624200024

BibTex

@inproceedings{BUT189075,
  author="SITA, J. and ČEPA, M. and VELEBNÝ, V. and ONDREÁŠ, F.",
  title="OLEYL-HYALURONAN SELF-ASSEMBLY AND ITS INTERACTIONS WITH BOVINE SERUM ALBUMIN",
  booktitle="PROCEEDINGS OF THE 18TH INTERNATIONAL CONFERENCE ON POLYSACCHARIDES-GLYCOSCIENCE",
  year="2022",
  pages="110--113",
  isbn="978-80-88307-12-9",
  url="https://www.webofscience.com/wos/woscc/full-record/WOS:001249624200024"
}