Project detail

Personalized bone reconstruction with fast-osseointegrative and antibacterial titanium implants after osteosarcoma surgical resection

Duration: 01.05.2024 — 31.12.2027

Funding resources

Ministerstvo zdravotnictví ČR - Program na podporu zdravotnického aplikovaného výzkumu na léta 2024 – 2030 - 1. VS

- whole funder (2024-04-12 - 2027-12-31)

On the project

Project is focused on the healing of critical segmental bone defects, which are made during a surgical treatment of cancers, using innovative scaffolds based on titanium. Porous composite scaffolds from titanium alloy Ti-Cu, Ti-Nb and Ti/hydroxyapatite will be prepared. Ti-Cu scaffolds display antibacterial effects and others scaffolds will be developed for improved osteointegration. All the materials are produced by extrusion base additive manufacturing (robocasting), a more cost effective and versatile additive manufacturing method that selective laser melting (SLM), commonly used for the fabrication of Ti-6Al-4V implants. The scaffolds will be tested in cocultures in vitro using human mesenchymal stem cells isolated from bone marrow, Saos-2 cells and endothelial cells for the study of osteogenesis and angiogenesis and THP-1 cells -derived macrophages for the study of immune reactions. Subsequently, the selected scaffolds will be tested in vivo for healing of critical bone defects in a model of rabbit and pig.

Keywords
titanium, composite, scaffold, osteosarcoma, implnat, prosthesis

Mark

NW24-10-00195

Default language

English

People responsible

Montufar Jimenez Edgar Benjamin, M.Sc., Ph.D. - principal person responsible

Units

Advanced Coatings
- beneficiary (2023-06-28 - not assigned)

Results

OLIVER URRUTIA, C.; CASAS LUNA, M.; KOLEDOVÁ, Z.; SLÁMEČKA, K.; ZIKMUND, T.; KAISER, J.; ČELKO, L.; MONTUFAR JIMENEZ, E. Fabrication of customized open-cell titanium foams by direct foaming for biomedical applications. Journal of Materials Research and Technology, 2024, vol. 33, no. 11, p. 1704-1714. ISSN: 2238-7854.
Detail

OLIVER URRUTIA, C.; KASHIMBETOVA, A.; SLÁMEČKA, K.; CASAS LUNA, M.; MATULA, J.; KOLEDOVÁ, Z.; KAISER, J.; ČELKO, L.; MONTUFAR JIMENEZ, E. Porous titanium/hydroxyapatite interpenetrating phase composites with optimal mechanical and biological properties for personalized bone repair. BIOMATERIALS ADVANCES, 2025, vol. 166, no. 214079, ISSN: 2772-9508.
Detail

DROTÁROVÁ, L.; SLÁMEČKA, K.; BALINT, M.; REMEŠOVÁ, M.; HUDÁK, R.; ŽIVČÁK, J.; ČELKO, L.; MONTUFAR JIMENEZ, E. Biodegradable WE43 Mg alloy/hydroxyapatite interpenetrating phase composites with reduced hydrogen evolution. Bioactive Materials, 2024, vol. 42, no. 12, p. 519-530. ISSN: 2452-199X.
Detail

Responsibility: Montufar Jimenez Edgar Benjamin, M.Sc., Ph.D.