Czech

Not applicable.

This course provides students especially the ability to:

Working with laboratory equipment and measuring instruments for conventional organic syntheses.
Experience with preaparation of organic substances in the laboratory scale.
Experience with occupational safety and health in the chemical laboratory work with organic compounds.

The knowledge of basic laboratory practices and techniques (recrystallization, distillation, extraction, etc.).
Passing the test of Organic Chemistry I.

Not applicable.

The course uses teaching methods in form of Laboratory exercise - 6 teaching hours per week. The e-learning system (LMS Moodle) is available to teachers and students.

To obtain the credit, the student must:
Passing 7 jobs during the semester.
To master the theoretical principles of tasks.
Submit prepared and adjusted products.
Submit a fully developed laboratory protocols.

Students are briefed by organization of laboratory and syntheses in detail during the first lab. Safety training is also realized. Students realize at least 7 syntheses of the following:
1. 3-Nitroaniline (nitration and partial reduction of nitro compound)
2. Ethylbromide a tert-butylchloride (SN)
3. Ethyl acetate (esterification)
4. 2,4-Dinitrophenyl hydrazine and hid hydrazones (SNAr and preparation of hydrazone)
5. Benzilic acid (benzoin condenzation, oxidation of alcohole and benzylic reargement)
6. Chlorobenzene (diazotation and Sandmeyer reaction)
7. Anhydride of bicyclo[2.2.1]hept-2-ene-5,6-dicarboxylic acid and bicyclo[2.2.1]-hept-2-ene-5,6-dicarboxylic acid (Diels-Alder's reaction)
8. Phenacetine (acylation of amine and Wiliamson's reaction)
9. Acid Red 150 (diazotation and copulation)
10. ß -Nitrostyrene (10a) a 1,5-difenylpenta-1,4-dien-3-one (10b) (reaction of carbonyl compounds)
11. Diphenylmethanol (preparation and reaction of Grignard reagent)
12. 2-(-4-Toluoyl)benzoic acid (Friedel-Crafts reaction)
Labs at last week of the term are substitute for unqualified or sick students during the term.
Detailed manuals and literature for each task are available on https://www.vutbr.cz/elearning/course/view.php?id=121977

Not applicable.

The basis of the course is to enhance the adoption and expansion of basic laboratory methods and techniques (eg work at reduced temperatures, vacuum distillation, steam distillation) in the synthesis and analysis of organic compounds (determination of melting point, refractive index). Tasks are chosen so as to include the most common and most important types of chemical reactions discussed in hours organic chemistry.

Checked attendance, protocols, submission of prepared compounds and determining their properties (melting point, boiling point, index of refraction).

Not applicable.

Not applicable.

https://www.vutbr.cz/elearning/course/view.php?id=121977 (CS)
Kizlink J., Bednařík, K.: Návody pro laboratorní praktikum z organické chemie. VUT, Brno 2009. (CS)

Nováček E., Potáček M., Janků S.: Laboratorní technika ke cvičení z metod organické chemie. MU, Brno 2000. (CS)
Pazdera P., Potáček M.: Cvičení z metod organické chemie. MU, Brno 1997. (CS)
Sandler S.R., Karo W.: Sourcebook of Advanced Organic Laboratory Preparations. Academic Press, San Diego 1992. (CS)