Detail projektu

Optoelectronic medicine - nerve cell regulation with light (OPTEL-MED)

Období řešení: 01.01.2021 — 31.12.2025

Zdroje financování

Evropská unie - Horizon 2020

- plně financující (2020-10-22 - 2025-12-31)

O projektu

Bioelectronic medicine today is growing in leaps and bounds, with ambitious new technologies entering the clinic and already changing the lives of more than a million patients worldwide. Materials scientists are called to craft biomedical devices that are smaller, smarter, and less invasive. We propose to create implantable photovoltaic devices which can wirelessly stimulate the nervous system and enable a new type of minimally invasive optoelectronic medicine. To achieve this, we will use biocompatible organic semiconductors which can efficiently absorb light in the near infrared part of the spectrum, where biological tissues are transparent. By micropatterning stimulation pixels on ultrathin conformable substrates, we will create optoelectronic nerve cuff electrodes which will be orders-of-magnitude thinner than what is used clinically today. We will explore deeply the physics of this new type of electrolytic photovoltaic stimulator. The designs will be optimized to operate with safe light intensities delivered from outside of the body. Benchmarking the targeting of precise optoelectronic stimulation will be done in ex vivo and in vivo nerve models. Via control of spatial patterning and localized light actuation, we will develop unique understanding of highly specific and nuanced neural control. The unique aspect of precise neuromodulation wirelessly positions us to explore a number of fundamental questions in applied neuroscience.

Klíčová slova
bioelectronics, neuromodulation, neural engineering, cellular photostimulation, organic electronics

Označení

949191

Originální jazyk

angličtina

Řešitelé

Glowacki Eric Daniel, prof., Ph.D. - hlavní řešitel

Útvary

Bioelektronické materiály a systémy
- příjemce (01.01.2021 - 31.12.2025)
Středoevropský technologický institut VUT
- odpovědné pracoviště (02.09.2020 - 23.11.2020)

Výsledky

GLOWACKI, E. Understanding Photocapacitive and Photofaradaic Processes in Organic Semiconductor Photoelectrodes for Optobioelectronics. ADVANCED FUNCTIONAL MATERIALS, 2021, vol. 31, no. 16, p. 1-10. ISSN: 1616-301X.
Detail

JAKEŠOVÁ, M.; KUNOVSKÝ, O.; GABLECH, I.; KHODAGHOLY, D.; GELINAS, J.; GLOWACKI, E. Coupling of photovoltaics with neurostimulation electrodes-optical to electrolytic transduction. Journal of Neural Engineering, 2024, vol. 21, no. 4, ISSN: 1741-2552.
Detail

EHLICH, J.; MIGLIACCIO, L.; NIKIĆ, M.; BRODSKÝ, J.; GABLECH, I.; GLOWACKI, E. Oxygen Reduction Reactions at Neurostimulation Electrodes. Zagreb, Croatia: CROATIAN NEUROELECTRONICS SYMPOSIUM / ZAGREB BIOELECTRONICS WORKSHOP 2021, 2021.
Detail

EHLICH, J.; MIGLIACCIO, L.; NIKIĆ, M.; BRODSKÝ, J.; GABLECH, I.; GLOWACKI, E. Oxygen Reduction Reactions at Neurostimulation Electrodes. Brno: Chemistry and Life, Faculty of Chemistry, Brno University of Technology, 2021.
Detail

BERGGREN, M.; GLOWACKI, E.; SIMON, D.; STAVRINIDIOU, E.; TYBRANDT, K. In Vivo Organic Bioelectronics for Neuromodulation. Chemical Reviews, 2022, vol. 122, no. 4, p. 4826-4846. ISSN: 0009-2665.
Detail

EJNEBY, M.; JAKEŠOVÁ, M.; FERRERO, J.; MIGLIACCIO, L.; SAHALIANOV, I.; ZHAO, Z.; BERGGREN, M.; KHODAGHOLY, D.; DEREK, V.; GELINAS, J.; GLOWACKI, E. Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor. Nature Biomedical Engineering, 2021, vol. 6, no. 1, p. 741-753. ISSN: 2157-846X.
Detail

VEBRAITE, I.; DAVID-PUR, M.; RAND, D.; GLOWACKI, E.; HANEIN, Y. Electrophysiological investigation of intact retina with soft printed organic neural interface. Journal of Neural Engineering, 2021, vol. 18, no. 6, p. 066017-1 (066017-12 p.)ISSN: 1741-2552.
Detail

MISSEY, F.; BOTZANOWSKI, B.; MIGLIACCIO, L.; ACERBO, E.; GLOWACKI, E.; WILLIAMSON, A. Organic electrolytic photocapacitors for stimulation of the mouse somatosensory cortex. Journal of Neural Engineering, 2021, vol. 18, no. 6, p. 1-11. ISSN: 1741-2552.
Detail

GRYSZEL, M.; JAKEŠOVÁ, M.; LEDNICKÝ, T.; GLOWACKI, E. High-Capacitance Nanoporous Noble Metal Thin Films via Reduction of Sputtered Metal Oxides. Advanced Materials Interfaces, 2022, vol. 9, no. 5, p. 2101973-1 (2101973-6 p.)ISSN: 2196-7350.
Detail

ABUDLLAEVA, O.; SAHALIANOV, I.; EJNEBY, M.; JAKEŠOVÁ, M.; ZOZOULENKO, I.; LIIN, S.; GLOWACKI, E. Faradaic Pixels for Precise Hydrogen Peroxide Delivery to Control M-Type Voltage-Gated Potassium Channels. Advanced Science, 2022, vol. 9, no. 3, p. 1-14. ISSN: 2198-3844.
Detail

NIKIĆ, M.; OPANCAR, A.; HARTMANN, F.; MIGLIACCIO, L.; JAKEŠOVÁ, M.; GLOWACKI, E.; DEREK, V. Micropyramid structured photo capacitive interfaces. Nanotechnology, 2022, vol. 33, no. 24, p. 1-9. ISSN: 1361-6528.
Detail

MISSEY, F.; DONAHUE, M.; WEBER, P.; NGOM, I.; ACERBO, E.; BOTZANOWSKI, B.; MIGLIACCIO, L.; JIRSA, V.; GLOWACKI, E.; WILLIAMSON, A. Laser-Driven Wireless Deep Brain Stimulation using Temporal Interference and Organic Electrolytic Photocapacitors. ADVANCED FUNCTIONAL MATERIALS, 2022, vol. 32, no. 33, p. 2200691-1 (2200691-8 p.)ISSN: 1616-301X.
Detail

EHLICH, J.; MIGLIACCIO, L.; SAHALIANOV, I.; NIKIĆ, M.; BRODSKÝ, J.; GABLECH, I.; VU, X.; INGEBRANDT, S.; GLOWACKI, E. Direct measurement of oxygen reduction reactions at neurostimulation electrodes. Journal of Neural Engineering, 2022, vol. 19, no. 3, p. 036045 ( p.)ISSN: 1741-2552.
Detail

SCHMIDT, T.; JAKEŠOVÁ, M.; DEREK, V.; KORNMUELLER, K.; TIAPKO, O.; BISCHOF, H.; BURGSTALLER, S.; WALDHERR, L.; NOWAKOWSKA, M.; BAUMGARTNER, C.; UCAL, M.; LEITINGER, G.; SCHERUEBEL, S.; PATZ, S.; MALLI, R.; GLOWACKI, E.; RIENMUELLER, T.; SCHINDL, R. Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision. Advanced Materials Technologies, 2022, vol. 7, no. 9, p. 2101159 ( p.)ISSN: 2365-709X.
Detail

SAY, M.; SAHALIANOV, I.; BROOKE, R.; MIGLIACCIO, L.; GLOWACKI, E.; BERGGREN, M.; DONAHUE, M.; ENGQUIST, I. Ultrathin Paper Microsupercapacitors for Electronic Skin Applications. Advanced Materials Technologies, 2022, vol. 7, no. 8, ISSN: 2365-709X.
Detail

BOTZANOWSKI, B.; DONAHUE, M.; EJNEBY, M.; GALLINA, A.L.; NGOM, I.; MISSEY, F.; ACERBO, E.; BYUN, D.; CARRON, R.; CASSARA, A.M.; NEUFELD, E.; JIRSA, V.; OLOFSSON, P.S.; GLOWACKI, E.; WILLIAMSON, A. Noninvasive Stimulation of Peripheral Nerves using Temporally-Interfering Electrical Fields. Journal of Interconnection Networks, 2022, vol. 11, no. 17, ISSN: 2192-2659.
Detail

DONAHUE, M.; EJNEBY, M.; JAKEŠOVÁ, M.; CARAVACA, A.; ANDERSSON, G.; SAHALIANOV, I.; DEREK, V.; HULT, H.; OLOFSSON, P.S.; GLOWACKI, E. Wireless optoelectronic devices for vagus nerve stimulation in mice. Journal of Neural Engineering, 2022, vol. 19, no. 6, ISSN: 1741-2552.
Detail

Rybakiewicz-Sekita, R.; Gryszel, M.; Pathak, G.; Ganczarczyk, R.; Donahue, MJ.; Glowacki, ED. Well-defined electrochemical switching of amphiphilic glycolated poly(3,4-ethylenedioxythiophene). Journal of Materials Chemistry C, 2022, vol. 10, no. 45, p. 17208-17215. ISSN: 2050-7526.
Detail

GABLECH, I.; MIGLIACCIO, L.; BRODSKÝ, J.; HAVLÍČEK, M.; PODEŠVA, P.; HRDÝ, R.; EHLICH, J.; GRYSZEL, M.; GLOWACKI, E. High-Conductivity Stoichiometric Titanium Nitride for Bioelectronics. Advanced Electronic Materials, 2023, vol. 9, no. 4, p. 1-11. ISSN: 2199-160X.
Detail

BRODSKÝ, J.; GABLECH, I.; MIGLIACCIO, L.; HAVLÍČEK, M.; DONAHUE, M.; GLOWACKI, E. Downsizing the Channel Length of Vertical Organic Electrochemical Transistors. ACS APPL MATER INTER, 2023, vol. 15, no. 22, p. 27002-27009. ISSN: 1944-8244.
Detail

MIGLBAUER, E.; ABUDLLAEVA, O.; GRYSZEL, M.; GLOWACKI, E. Faradaic Fenton Pixel: Reactive Oxygen Species Delivery Using Au/Cr Electrochemistry. Chembiochem : a European journal of chemical biology, 2023, vol. 24, no. 17, p. 1-14. ISSN: 1439-7633.
Detail

GABLECH, I.; GLOWACKI, E. State-of-the-Art Electronic Materials for Thin Films in Bioelectronics. Advanced Electronic Materials, 2023, vol. 9, no. 8, p. 1-23. ISSN: 2199-160X.
Detail

GANCZARCZYK, R.; RYBAKIEWICZ-SEKITA, R.; GRYSZEL, M.; DRÁPALA, J.; ZAGÓRSKA, M.; GLOWACKI, E. Polymeric Benzothiadiazole, Benzooxadiazole, and Benzoselenadiazole Photocathodes for Photocatalytic Oxygen Reduction to Hydrogen Peroxide. Advanced Materials Interfaces, 2023, vol. 10, no. 21, ISSN: 2196-7350.
Detail

GRYSZEL, M.; SCHLOSSAREK, T.; WÜRTHNER, F.; NATALI, M.; GLOWACKI, E. Water-Soluble Cationic Perylene Diimide Dyes as Stable Photocatalysts for H2O2 Evolution. ChemPhotoChem, 2023, vol. 7, no. 9, p. 1-9. ISSN: 2367-0932.
Detail

Savva, A.; Hama, A.; Herrera-López, G.; Schmidt, T.; Migliaccio, L.; Steiner, N.; Kawan, M.; Fiumelli, H.; Magistretti, PJ.; Mcculloch, I.; Baran, D.; Gasparini, N.; Schindl, R.; Glowacki, ED.; Inal, S. Photo-Chemical Stimulation of Neurons with Organic Semiconductors. Advanced Science, 2023, vol. 10, no. 31, ISSN: 2198-3844.
Detail

GRYSZEL, M.; JAKEŠOVÁ, M.; VU, X.; INGEBRANDT, S.; GLOWACKI, E. Elevating Platinum to Volumetric Capacitance: High Surface Area Electrodes through Reactive Pt Sputtering. Advanced Healthcare Materials, 2024, vol. 13, no. 5, ISSN: 2192-2640.
Detail

NOWAKOWSKA, M.; JAKEŠOVÁ, M.; SCHMIDT, T.; OPANČAR, A.; REIMER, R.; POLZ, M.; PATZ, S.; FUCHS, J.; ZIESEL, D.; SCHERUEBEL, S.; KORNMUELLER, K.; RIENMÜLLER, T.; DEREK, V.; GLOWACKI, E.; SCHINDL, R.; ÜÇAL, M. Light-Controlled Electric Stimulation with Organic Electrolytic Photocapacitors Achieves Complex Neuronal Network Activation: Semi-Chronic Study in Cortical Cell Culture and Rat Model. Advanced Healthcare Materials, 2024, vol. 2024, no. 2401303, ISSN: 2192-2640.
Detail

GLOWACKI, E.; JAKEŠOVÁ, M.; NIKIĆ, M. Scalable Microfabrication of Folded Parylene-Based Conductors for Stretchable Electronics. Advanced Electronic Materials, 2021, vol. 7, no. 4, p. 2001236-1 (2001236-7 p.)ISSN: 2199-160X.
Detail

Odpovědnost: Glowacki Eric Daniel, prof., Ph.D.