Bioelectronic medicine today is growing in leaps and bounds, with ambitious new technologies entering the clinic and already changing the lives of more than a million patients worldwide. Materials scientists are called to craft biomedical devices that are smaller, smarter, and less invasive. We propose to create implantable photovoltaic devices which can wirelessly stimulate the nervous system and enable a new type of minimally invasive optoelectronic medicine. To achieve this, we will use biocompatible organic semiconductors which can efficiently absorb light in the near infrared part of the spectrum, where biological tissues are transparent. By micropatterning stimulation pixels on ultrathin conformable substrates, we will create optoelectronic nerve cuff electrodes which will be orders-of-magnitude thinner than what is used clinically today. We will explore deeply the physics of this new type of electrolytic photovoltaic stimulator. The designs will be optimized to operate with safe light intensities delivered from outside of the body. Benchmarking the targeting of precise optoelectronic stimulation will be done in ex vivo and in vivo nerve models. Via control of spatial patterning and localized light actuation, we will develop unique understanding of highly specific and nuanced neural control. The unique aspect of precise neuromodulation wirelessly positions us to explore a number of fundamental questions in applied neuroscience.

Klíčová slova
bioelectronics, neuromodulation, neural engineering, cellular photostimulation, organic electronics

949191

angličtina

Glowacki Eric Daniel, prof., Ph.D. - hlavní řešitel

Bioelektronické materiály a systémy
- odpovědné pracoviště (23.11.2020 - nezadáno)
Středoevropský technologický institut VUT
- odpovědné pracoviště (2.9.2020 - 23.11.2020)
Bioelektronické materiály a systémy
- příjemce (1.1.2021 - 31.12.2025)

MIGLIACCIO, L.; SAY, M.; PATHAK, G.; GABLECH, I.; BRODSKÝ, J.; DONAHUE, M.; GLOWACKI, E. Ultrathin Indium Tin Oxide Accumulation Mode Electrolyte-Gated Transistors for Bioelectronics. Advanced Materials Technologies, 2025, vol. 10, no. 4, p. 2302219 ( p.)ISSN: 2365-709X.
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EHLICH, J.; VAŠÍČEK, Č.; DOBEŠ, J.; RUGGIERO, A.; VEJVODOVÁ, M.; GLOWACKI, E. Shattering the Water Window: Comprehensive Mapping of Faradaic Reactions on Bioelectronics Electrodes. ACS applied materials & interfaces, 2024, vol. 16, no. 40, p. 53567-53576. ISSN: 1944-8252.
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OPANČAR, A.; GLOWACKI, E.; DEREK, V. Choosing the right electrode representation for modeling real bioelectronic interfaces: a comprehensive guide. J NEURAL ENG, 2024, vol. 21, no. 4, p. 1-17. ISSN: 1741-2560.
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JAKEŠOVÁ, M.; KUNOVSKÝ, O.; GABLECH, I.; KHODAGHOLY, D.; GELINAS, J.; GLOWACKI, E. Coupling of photovoltaics with neurostimulation electrodes-optical to electrolytic transduction. Journal of Neural Engineering, 2024, vol. 21, no. 4, ISSN: 1741-2552.
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NOWAKOWSKA, M.; JAKEŠOVÁ, M.; SCHMIDT, T.; OPANČAR, A.; POLZ, M.; REIMER, R.; FUCHS, J.; PATZ, S.; ZIESEL, D.; SCHERUEBEL, S.; KORNMUELLER, K.; RIENMÜLLER, T.; DEREK, V.; GLOWACKI, E.; SCHINDL, R.; ÜÇAL, M. Light-Controlled Electric Stimulation with Organic Electrolytic Photocapacitors Achieves Complex Neuronal Network Activation: Semi-Chronic Study in Cortical Cell Culture and Rat Model. Advanced Healthcare Materials, 2024, vol. 13, no. 29, p. 1-19. ISSN: 2192-2640.
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GRYSZEL, M.; JAKEŠOVÁ, M.; VU, X.; INGEBRANDT, S.; GLOWACKI, E. Elevating Platinum to Volumetric Capacitance: High Surface Area Electrodes through Reactive Pt Sputtering. Advanced Healthcare Materials, 2024, vol. 13, no. 5, ISSN: 2192-2640.
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Savva, A.; Hama, A.; Herrera-López, G.; Schmidt, T.; Migliaccio, L.; Steiner, N.; Kawan, M.; Fiumelli, H.; Magistretti, PJ.; Mcculloch, I.; Baran, D.; Gasparini, N.; Schindl, R.; Glowacki, ED.; Inal, S. Photo-Chemical Stimulation of Neurons with Organic Semiconductors. Advanced Science, 2023, vol. 10, no. 31, ISSN: 2198-3844.
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GRYSZEL, M.; SCHLOSSAREK, T.; WÜRTHNER, F.; NATALI, M.; GLOWACKI, E. Water-Soluble Cationic Perylene Diimide Dyes as Stable Photocatalysts for H2O2 Evolution. ChemPhotoChem, 2023, vol. 7, no. 9, p. 1-9. ISSN: 2367-0932.
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GANCZARCZYK, R.; RYBAKIEWICZ-SEKITA, R.; GRYSZEL, M.; DRÁPALA, J.; ZAGÓRSKA, M.; GLOWACKI, E. Polymeric Benzothiadiazole, Benzooxadiazole, and Benzoselenadiazole Photocathodes for Photocatalytic Oxygen Reduction to Hydrogen Peroxide. Advanced Materials Interfaces, 2023, vol. 10, no. 21, ISSN: 2196-7350.
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GABLECH, I.; GLOWACKI, E. State-of-the-Art Electronic Materials for Thin Films in Bioelectronics. Advanced Electronic Materials, 2023, vol. 9, no. 8, p. 1-23. ISSN: 2199-160X.
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MIGLBAUER, E.; ABUDLLAEVA, O.; GRYSZEL, M.; GLOWACKI, E. Faradaic Fenton Pixel: Reactive Oxygen Species Delivery Using Au/Cr Electrochemistry. Chembiochem : a European journal of chemical biology, 2023, vol. 24, no. 17, p. 1-14. ISSN: 1439-7633.
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BRODSKÝ, J.; GABLECH, I.; MIGLIACCIO, L.; HAVLÍČEK, M.; DONAHUE, M.; GLOWACKI, E. Downsizing the Channel Length of Vertical Organic Electrochemical Transistors. ACS APPL MATER INTER, 2023, vol. 15, no. 22, p. 27002-27009. ISSN: 1944-8244.
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GABLECH, I.; MIGLIACCIO, L.; BRODSKÝ, J.; HAVLÍČEK, M.; PODEŠVA, P.; HRDÝ, R.; EHLICH, J.; GRYSZEL, M.; GLOWACKI, E. High-Conductivity Stoichiometric Titanium Nitride for Bioelectronics. Advanced Electronic Materials, 2023, vol. 9, no. 4, p. 1-11. ISSN: 2199-160X.
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Rybakiewicz-Sekita, R.; Gryszel, M.; Pathak, G.; Ganczarczyk, R.; Donahue, MJ.; Glowacki, ED. Well-defined electrochemical switching of amphiphilic glycolated poly(3,4-ethylenedioxythiophene). Journal of Materials Chemistry C, 2022, vol. 10, no. 45, p. 17208-17215. ISSN: 2050-7526.
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DONAHUE, M.; EJNEBY, M.; JAKEŠOVÁ, M.; CARAVACA, A.; ANDERSSON, G.; SAHALIANOV, I.; DEREK, V.; HULT, H.; OLOFSSON, P.S.; GLOWACKI, E. Wireless optoelectronic devices for vagus nerve stimulation in mice. Journal of Neural Engineering, 2022, vol. 19, no. 6, ISSN: 1741-2552.
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BOTZANOWSKI, B.; DONAHUE, M.; EJNEBY, M.; GALLINA, A.L.; NGOM, I.; MISSEY, F.; ACERBO, E.; BYUN, D.; CARRON, R.; CASSARA, A.M.; NEUFELD, E.; JIRSA, V.; OLOFSSON, P.S.; GLOWACKI, E.; WILLIAMSON, A. Noninvasive Stimulation of Peripheral Nerves using Temporally-Interfering Electrical Fields. Journal of Interconnection Networks, 2022, vol. 11, no. 17, ISSN: 2192-2659.
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SAY, M.; SAHALIANOV, I.; BROOKE, R.; MIGLIACCIO, L.; GLOWACKI, E.; BERGGREN, M.; DONAHUE, M.; ENGQUIST, I. Ultrathin Paper Microsupercapacitors for Electronic Skin Applications. Advanced Materials Technologies, 2022, vol. 7, no. 8, ISSN: 2365-709X.
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SCHMIDT, T.; JAKEŠOVÁ, M.; DEREK, V.; KORNMUELLER, K.; TIAPKO, O.; BISCHOF, H.; BURGSTALLER, S.; WALDHERR, L.; NOWAKOWSKA, M.; BAUMGARTNER, C.; UCAL, M.; LEITINGER, G.; SCHERUEBEL, S.; PATZ, S.; MALLI, R.; GLOWACKI, E.; RIENMUELLER, T.; SCHINDL, R. Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision. Advanced Materials Technologies, 2022, vol. 7, no. 9, p. 2101159 ( p.)ISSN: 2365-709X.
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EHLICH, J.; MIGLIACCIO, L.; SAHALIANOV, I.; NIKIĆ, M.; BRODSKÝ, J.; GABLECH, I.; VU, X.; INGEBRANDT, S.; GLOWACKI, E. Direct measurement of oxygen reduction reactions at neurostimulation electrodes. Journal of Neural Engineering, 2022, vol. 19, no. 3, p. 036045 ( p.)ISSN: 1741-2552.
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MISSEY, F.; DONAHUE, M.; WEBER, P.; NGOM, I.; ACERBO, E.; BOTZANOWSKI, B.; MIGLIACCIO, L.; JIRSA, V.; GLOWACKI, E.; WILLIAMSON, A. Laser-Driven Wireless Deep Brain Stimulation using Temporal Interference and Organic Electrolytic Photocapacitors. ADVANCED FUNCTIONAL MATERIALS, 2022, vol. 32, no. 33, p. 2200691-1 (2200691-8 p.)ISSN: 1616-301X.
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Odpovědnost: Glowacki Eric Daniel, prof., Ph.D.